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C4S-PTPRZ1 [plasma membrane]
Stable Identifier
R-HSA-9699799
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RPTPzeta, Receptor-type tyrosine-protein phosphatase zeta, PTPRZ_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
MDK and PTN in ALK signaling (Homo sapiens)
(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)
(PTN,MDK):PTPRZ [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Homo sapiens)
(PTN,MDK):PTPRZ [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
PTN and MDK bind to PTPRZ (Homo sapiens)
(PTN,MDK):PTPRZ [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Homo sapiens)
(PTN,MDK):PTPRZ [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
C4S-PTPRZ1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23471 PTPRZ1
Gene Names
PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ
Chain
signal peptide:1-24, chain:25-2315
Reference Genes
BioGPS Gene:5803 PTPRZ1
COSMIC (genes):PTPRZ1 PTPRZ1
CTD Gene:5803 PTPRZ1
dbSNP Gene:5803 PTPRZ1
ENSEMBL:ENSG00000106278 PTPRZ1
ENSEMBL_homo_sapiens_GENE:ENSG00000106278.12 PTPRZ1
HGNC:9685 PTPRZ1
KEGG Gene (Homo sapiens):5803 PTPRZ1
Monarch:5803 PTPRZ1
NCBI Gene:5803 PTPRZ1
OMIM:176891 PTPRZ1
OMIM:604008 PTPRZ1
UCSC:P23471 PTPRZ1
Reference Transcript
RefSeq:NM_001206839.1 PTPRZ1
RefSeq:NM_002851.2 PTPRZ1
RefSeq:XM_005250519.1 PTPRZ1
RefSeq:NM_001206838.1 PTPRZ1
Other Identifiers
11719443_at
11719444_s_at
11746144_a_at
1364_at
17050847
204469_PM_at
204469_at
3021378
3021379
3021380
3021396
3021408
3021409
3021410
3021411
3021416
3021417
3021419
3021421
3021422
3021424
3021426
3021427
3021428
3021429
3021430
3021431
3021432
3021433
3021434
3021435
3021436
3021437
3021442
3021444
3021446
3021451
3021452
3021453
3021454
3021456
3021457
3021458
3021460
3021461
3021462
3021464
3021466
3021468
3021470
3021471
5803
8135774
A_14_P119963
A_14_P126939
A_23_P168761
A_24_P235248
A_24_P8474
GE58152
GO:0002244
GO:0003824
GO:0004721
GO:0004725
GO:0005001
GO:0005178
GO:0005515
GO:0005576
GO:0005886
GO:0006470
GO:0007409
GO:0007417
GO:0007611
GO:0012501
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0030154
GO:0030312
GO:0031012
GO:0031641
GO:0035335
GO:0036211
GO:0043524
GO:0045202
GO:0048709
GO:0048714
GO:0048856
GO:0050877
GO:0060089
GO:0070445
GO:0072534
GO:0140096
HMNXSV003053121
ILMN_1676616
M93426_at
TC07000738.hg
g4506328_3p_at
Participates
as an input of
PTN and MDK bind to PTPRZ (Homo sapiens)
as a component of
(PTN,MDK):PTPRZ [plasma membrane] (Homo sapiens)
Other forms of this molecule
PTPRZ1 [plasma membrane]
Inferred To
C4S-PTPRZ1 [plasma membrane]
(Gallus gallus)
C4S-PTPRZ1 [plasma membrane]
(Mus musculus)
C4S-PTPRZ1 [plasma membrane]
(Rattus norvegicus)
PTPRZ1 [plasma membrane]
(Bos taurus)
PTPRZ1 [plasma membrane]
(Canis familiaris)
PTPRZ1 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 637
Coordinate
637
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1549
Coordinate
1549
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1551
Coordinate
1551
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 997
Coordinate
997
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_005250576.1
,
NP_001193767.1
,
NP_001193768.1
,
NP_002842.2
Guide to Pharmacology - Targets
1869
OpenTargets
ENSG00000106278
GeneCards
P23471
HPA
ENSG00000106278-PTPRZ1
Ensembl
ENST00000393386
,
ENSP00000410000
,
ENST00000652298
,
ENSP00000499137
,
ENSG00000106278
,
ENST00000449182
,
ENSP00000377047
PRO
P23471
Pharos - Targets
P23471
HMDB Protein
HMDBP08953
PDB
8FN9
,
3JXF
,
8FN8
,
3S97
,
5AWX
,
5H08
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12860 CNTN1
1
CNTN1 [plasma membrane]
(R-HSA-373622)
0.611
3
UniProt:Q9UM73 ALK
20
p-7Y ALK T1087I [plasma membrane]
(R-HSA-9723885)
p-7Y ALK R1061Q [plasma membrane]
(R-HSA-9723884)
p-7Y ALK L1196M [plasma membrane]
(R-HSA-9700464)
p-7Y ALK M1166R [plasma membrane]
(R-HSA-9700477)
p-Y ALK S1206C [plasma membrane]
(R-HSA-9715292)
p- 7Y ALK L1122V [plasma membrane]
(R-HSA-9715294)
p-7Y ALK E1384K [plasma membrane]
(R-HSA-9715285)
p-7Y ALK L1196Q [plasma membrane]
(R-HSA-9700476)
p-7Y ALK V1180L [plasma membrane]
(R-HSA-9715289)
p-7Y ALK G1201R [plasma membrane]
(R-HSA-9701860)
p-7Y ALK I1171T [plasma membrane]
(R-HSA-9700489)
p-7Y ALK R1275L [plasma membrane]
(R-HSA-9699800)
p-7Y ALK F1174C [plasma membrane]
(R-HSA-9699821)
p-7Y ALK F1174V [plasma membrane]
(R-HSA-9699921)
p-7Y ALK M1166N [plasma membrane]
(R-HSA-9723299)
p-7Y ALK M1166T [plasma membrane]
(R-HSA-9700486)
p-7Y ALK Y1239H [plasma membrane]
(R-HSA-9715290)
p-7Y ALK R1275* [plasma membrane]
(R-HSA-9699915)
p-7Y ALK I1171S [plasma membrane]
(R-HSA-9714063)
p-7Y ALK G1128S [plasma membrane]
(R-HSA-9700462)
0.544
2
UniProt:P05106 ITGB3
3
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
ITGB3 [plasma membrane]
(R-HSA-57600)
0.463
2
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