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ALK G1201E [plasma membrane]
Stable Identifier
R-HSA-9701842
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ALK tyrosine kinase receptor, ALK_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Autophosphorylation of point mutants of ALK (Homo sapiens)
ALK point mutant dimers [plasma membrane] (Homo sapiens)
kinase domain ALK mutant dimers [plasma membrane] (Homo sapiens)
ALK G1201E dimer [plasma membrane] (Homo sapiens)
ALK G1201E [plasma membrane] (Homo sapiens)
Ligand-independent dimerization of point mutants of ALK (Homo sapiens)
ALK point mutant dimers [plasma membrane] (Homo sapiens)
kinase domain ALK mutant dimers [plasma membrane] (Homo sapiens)
ALK G1201E dimer [plasma membrane] (Homo sapiens)
ALK G1201E [plasma membrane] (Homo sapiens)
ALK point mutants [plasma membrane] (Homo sapiens)
kinase domain ALK mutants [plasma membrane] (Homo sapiens)
ALK G1201E [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21596819
Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene
Xing, M
,
Murugan, AK
Cancer Res.
2011
External Reference Information
External Reference
UniProt:Q9UM73 ALK
Gene Names
ALK
Chain
signal peptide:1-18, chain:19-1620
Reference Genes
BioGPS Gene:238 ALK
COSMIC (genes):ALK ALK
CTD Gene:238 ALK
dbSNP Gene:238 ALK
ENSEMBL:ENSG00000171094 ALK
HGNC:427 ALK
Monarch:238 ALK
NCBI Gene:238 ALK
OMIM:105590 ALK
UCSC:Q9UM73 ALK
Reference Transcript
RefSeq:NM_004304.4 ALK
Other Identifiers
11740853_a_at
11750678_a_at
16896049
208211_PM_s_at
208211_s_at
208212_PM_s_at
208212_s_at
238
242964_PM_at
242964_at
2546408
2546410
2546411
2546412
2546413
2546414
2546415
2546416
2546417
2546418
2546420
2546423
2546424
2546429
2546430
2546431
2546432
2546433
2546434
2546436
2546437
2546439
2546440
2546441
2546442
2546444
2546450
2546458
2546459
2546464
2546468
2546470
2546471
2546472
2546479
2546492
2546493
2546508
2546511
2546512
2546542
2546543
38543_at
451_at
66494_at
8051241
81979_at
A_23_P10091
A_23_P324304
A_32_P37875
GE511598
GE81380
GE875695
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005886
GO:0006355
GO:0006468
GO:0006950
GO:0007165
GO:0007169
GO:0007399
GO:0007420
GO:0008201
GO:0016020
GO:0016310
GO:0016740
GO:0021766
GO:0030298
GO:0030534
GO:0032991
GO:0036269
GO:0038083
GO:0042127
GO:0042802
GO:0042981
GO:0043226
GO:0043235
GO:0045664
GO:0046777
GO:0048666
GO:0048856
GO:0050995
GO:0051092
GO:0060089
GO:0060159
GO:0070062
GO:0090648
GO:0097009
GO:0098772
GO:0140096
GO:1900006
HMNXSV003058035
Hs.161332.0.A1_3p_at
ILMN_1753135
PH_hs_0009802
PH_hs_0024837
TC02001708.hg
U66559_at
g1848243_3p_a_at
Participates
as a member of
kinase domain ALK mutants [plasma membrane] (Homo sapiens)
as a component of
ALK G1201E dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-7Y ALK T1087I [plasma membrane]
p-7Y ALK R1061Q [plasma membrane]
p-7Y ALK L1196M [plasma membrane]
p-7Y ALK M1166R [plasma membrane]
p-Y ALK S1206C [plasma membrane]
p- 7Y ALK L1122V [plasma membrane]
p-7Y ALK E1384K [plasma membrane]
p-7Y ALK L1196Q [plasma membrane]
p-7Y ALK V1180L [plasma membrane]
p-7Y ALK G1201R [plasma membrane]
p-7Y ALK I1171T [plasma membrane]
p-7Y ALK R1275L [plasma membrane]
p-7Y ALK F1174C [plasma membrane]
p-7Y ALK F1174V [plasma membrane]
p-7Y ALK M1166N [plasma membrane]
p-7Y ALK M1166T [plasma membrane]
p-7Y ALK Y1239H [plasma membrane]
p-7Y ALK R1275* [plasma membrane]
p-7Y ALK I1171S [plasma membrane]
p-7Y ALK G1128S [plasma membrane]
p-7Y ALK G1128V [plasma membrane]
p-7Y ALK H694R [plasma membrane]
p-7Y ALK G881D [plasma membrane]
p-7Y ALK V597A [plasma membrane]
p-7Y ALK S413N [plasma membrane]
ALK H694R [plasma membrane]
ALK del318-782 [plasma membrane]
ALK H224_G318del [plasma membrane]
ALK V597A [plasma membrane]
ALK S413N [plasma membrane]
ALK G881D [plasma membrane]
ALK T1087I [plasma membrane]
ALK K1062M [plasma membrane]
ALK R1061Q [plasma membrane]
ALK M1166R [plasma membrane]
ALK E1384K [plasma membrane]
ALK R1275* [plasma membrane]
ALK G1201R [plasma membrane]
ALK R1275L [plasma membrane]
ALK M1166N [plasma membrane]
ALK M1166T [plasma membrane]
ALK G1128V [plasma membrane]
ALK G1128S [plasma membrane]
ALK Y1239H [plasma membrane]
ALK F1174S [plasma membrane]
p-7Y ALK del224-318 [plasma membrane]
p-7Y ALK R1275Q [plasma membrane]
p-7Y ALK G1201E [plasma membrane]
p-7Y ALK K1062M [plasma membrane]
p-7Y ALK del318-782 [plasma membrane]
p-7Y ALK L1198F [plasma membrane]
p-7Y ALK R1192P [plasma membrane]
p-7Y ALK F1245C [plasma membrane]
p-7Y ALK G1128A [plasma membrane]
p-7Y ALK F1174S [plasma membrane]
p-7Y ALK I1171N [plasma membrane]
p-7Y ALK F1174L [plasma membrane]
p-7Y ALK F1174I [plasma membrane]
ALK G1128A [plasma membrane]
ALK S1206F [plasma membrane]
ALK T1151dup [plasma membrane]
ALK C1156Y [plasma membrane]
ALK R1192P [plasma membrane]
ALK T1151M [plasma membrane]
ALK L1122V [plasma membrane]
ALK L1152R [plasma membrane]
ALK A1234T [plasma membrane]
ALK D1203N [plasma membrane]
ALK L1198P [plasma membrane]
ALK G1202R [plasma membrane]
ALK I1171S [plasma membrane]
ALK S1206C [plasma membrane]
ALK F1174C [plasma membrane]
ALK I1171N [plasma membrane]
p-7Y-ALK [plasma membrane]
ALK G1269A [plasma membrane]
ALK F1174V [plasma membrane]
ALK I1171T [plasma membrane]
ALK V1180L [plasma membrane]
ALK F1174I [plasma membrane]
ALK S1206Y [plasma membrane]
ALK L1198F [plasma membrane]
ALK R1275Q [plasma membrane]
ALK F1174L [plasma membrane]
ALK L1196M [plasma membrane]
ALK G1269S [plasma membrane]
ALK L1196Q [plasma membrane]
ALK [plasma membrane]
Modified Residues
Name
glycine 1201 replaced with L-glutamic acid
Coordinate
1201
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-glutamic acid residue [MOD:00015]
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
Disease
Name
Identifier
Synonyms
thyroid carcinoma
DOID:3963
head and neck cancer, Thyroid
Cross References
ZINC - World Drugs
ALK_HUMAN
Guide to Pharmacology - Targets
1839
OpenTargets
ENSG00000171094
ENSEMBL
ENST00000389048
,
ENSP00000373700
ZINC - FDA approved
ALK_HUMAN
ZINC - Substances
ALK_HUMAN
ZINC - Biogenic
ALK_HUMAN
ZINC target
Q9UM73
PRO
Q9UM73
GlyGen
Q9UM73
PDB
5VZ5
,
3L9P
,
4JOA
,
4CCU
,
7LRZ
,
6MX8
,
4DCE
,
4FOC
,
5IUI
,
4CMO
,
4FOB
,
5A9U
,
5KZ0
,
4CLJ
,
5AA9
,
5AAB
,
2YJR
,
6E0R
,
7BTT
,
4FNZ
,
7MZW
,
2KUP
,
3AOX
,
4FNX
,
5AAC
,
7JY4
,
5IUH
,
2YHV
,
4ANQ
,
7NX4
,
7NWZ
,
4CCB
,
4CTB
,
8ARJ
,
7MZY
,
4ANL
,
6CDT
,
6EDL
,
2YJS
,
4FOD
,
5FTQ
,
2YFX
,
7JYT
,
2XP2
,
2YS5
,
7JYR
,
4FNW
,
4Z55
,
7LS0
,
6AT9
,
6EBW
,
4CMU
,
5AAA
,
5FTO
,
4CMT
,
5AA8
,
4CLI
,
5IMX
,
3LCS
,
2KUQ
,
4FNY
,
5IUG
,
7R7R
,
4CD0
,
7JYS
,
4MKC
,
2XBA
,
3LCT
,
7NX3
,
2YT2
,
4CNH
,
4CTC
,
4TT7
,
7R7K
,
7N00
,
2XB7
,
4ANS
ZINC - Investigational
ALK_HUMAN
ZINC - Metabolites
ALK_HUMAN
COSMIC
COSV66557297
HPA
ENSG00000171094-ALK
Pharos - Targets
Q9UM73
Orphanet
ALK
ZINC - Predictions - Purchasable
ALK_HUMAN
HMDB Protein
HMDBP01223
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UXT8 FAM150A
1
ALKAL1 [extracellular region]
(R-HSA-9842576)
0.655
7
ChEBI:64310 CRIZOTINIB
0.59
9
UniProt:P29353 SHC1
5
p-Y-SHC1 [cytosol]
(R-HSA-162568)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
0.569
3
ChEBI:62268 CH5424802
0.558
3
UniProt:Q6UX46 FAM150B
2
HC-ALKAL2 [extracellular region]
(R-HSA-9842575)
ALKAL2 [extracellular region]
(R-HSA-9842580)
0.556
5
UniProt:P23471 PTPRZ1
2
PTPRZ1 [plasma membrane]
(R-HSA-374561)
C4S-PTPRZ1 [plasma membrane]
(R-HSA-9699799)
0.544
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.524
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.499
2
UniProt:P29317 EPHA2
2
p-Y588,Y594-EPHA2 [plasma membrane]
(R-HSA-3928380)
EPHA2 [plasma membrane]
(R-HSA-211422)
0.483
2
UniProt:Q9Y2U8 LEMD3
4
LEMD3 [endosome membrane]
(R-HSA-9715091)
LEMD3 [endoplasmic reticulum membrane]
(R-HSA-9714458)
LEMD3 [plasma membrane]
(R-HSA-9715186)
LEMD3 [nuclear envelope]
(R-HSA-2993886)
0.483
2
UniProt:P29376 LTK
2
p-6Y-LTK [plasma membrane]
(R-HSA-9842578)
LTK [plasma membrane]
(R-HSA-9842564)
0.483
2
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