Purinergic signaling in leishmaniasis infection

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R-HSA-9660826
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Pathway
Species
Homo sapiens
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The purinoreceptors are divided into inotropic (P2XR) and metabotropic (P2YR) subtypes whose ligands are the nucleotides ATP and UDP respectively (Cekic et al. 2016). The binding of these nucleotides to their receptors on macrophages have been associated with the activation of the inflammasome leading to the subsequent activation of interleukin 1 beta (IL1β) and TNF-α (Cekic et al. 2016 & Figueiredo et al. 2016). The liberation of ATP comes from tissues facing stressful stimuli such as a tissue injury or microorganism infection, amongst others. As a regulatory mechanism, certain enzymes can reduce ATP to Adenosine and a nucleoside can stimulate signalling pathways leading to the synthesis of anti-inflammatory cytokines (Cekic et al. 2016).

The activation of the receptor P2RX7 was shown to lead to the activation of killing mechanisms or cell death programs, ending up in the elimination of microbes such as Leishmania amazonensis, Mycobacterium tuberculosis, Chlamydia psittaci, and Toxoplasma gondii (Coutinho-Silva et al. 2012 & Idzko, 2014).

Literature References
PubMed ID Title Journal Year
22634346 Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

Coutinho-Silva, R, Ojcius, DM

Microbes Infect. 2012
24828189 Nucleotide signalling during inflammation

Idzko, M, Ferrari, D, Eltzschig, HK

Nature 2014
27793266 Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response

Figueiredo, AB, Souza-Testasicca, MC, Afonso, LCC

Biomed J 2016
26922909 Purinergic regulation of the immune system

Cekic, C, Linden, J

Nat. Rev. Immunol. 2016
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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