NTPDase5 may function in the endoplasmic reticulum (ER), where its UDPase activity could contribute to protein glycosylation and folding. NTPDase5 may alleviate ER stress induced by protein overload caused by oncogenic PI3K/AKT signaling in cancer cells. NTPDase5 is over-expressed in tumors with activated AKT and is known as the PCPH oncogene. The underlying mechanism of NTPDase5 over-expression may be AKT-mediated inhibition of FOXO proteins, which are probable transcriptional repressors of the ENTPD5 gene (Fang et al. 2010, Shen et al. 2011).
Wang, X, Shen, Z, Mak, TW, Huang, S, Fang, M, Zhao, L, Chen, S
Huang, S, Shen, Z, Wang, X, Fang, M
Bright, JM, Yeung, G, Ford, JE, McGowan, DW, Nelken, ST, Mulero, JJ
Yeung, G, Ford, JE, Nelken, ST, Mulero, JJ
nucleoside diphosphate phosphatase activity of NPTDase5:Ca2+,Mg2+ [extracellular region]
© 2025 Reactome