Reactome | NTPDase5 hydrolyzes nucleoside diphosphates

NTPDase5 hydrolyzes nucleoside diphosphates

Stable Identifier

R-HSA-8851356

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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        NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)

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NTPDase5 hydrolyzes nucleoside diphosphates

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NTPDase5 (CD39L4), encoded by the ENTPD5 gene, is an E-NTPDase family member that is secreted to the extracellular space where it hydrolyzes nucleoside diphosphates UDP, GDP, CDP and ADP (listed in the order of preference) to nucleoside monophosphates UMP, GMP, CMP and AMP, respectively. In vitro, NTPDase5 can hydrolyze nucleoside triphosphates GTP, CTP, UTP and ATP to corresponding nucleoside diphosphates but with very low efficiency. NTPDase5 requires Ca2+ or Mg2+ for catalytic activity (Mulero et al. 1999). NTPDase5 is most catalytically active as a monomer, although it can also form disulfide-linked dimers (Mulero et al. 2000).

NTPDase5 may function in the endoplasmic reticulum (ER), where its UDPase activity could contribute to protein glycosylation and folding. NTPDase5 may alleviate ER stress induced by protein overload caused by oncogenic PI3K/AKT signaling in cancer cells. NTPDase5 is over-expressed in tumors with activated AKT and is known as the PCPH oncogene. The underlying mechanism of NTPDase5 over-expression may be AKT-mediated inhibition of FOXO proteins, which are probable transcriptional repressors of the ENTPD5 gene (Fang et al. 2010, Shen et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21074248	The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway Wang, X, Shen, Z, Mak, TW, Huang, S, Fang, M, Zhao, L, Chen, S	Cell	2010
22169232	ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells Huang, S, Shen, Z, Wang, X, Fang, M	Cold Spring Harb. Symp. Quant. Biol.	2011
11041857	Biochemical characterization of CD39L4 Bright, JM, Yeung, G, Ford, JE, McGowan, DW, Nelken, ST, Mulero, JJ	Biochemistry	2000
10400613	CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates Yeung, G, Ford, JE, Nelken, ST, Mulero, JJ	J. Biol. Chem.	1999