ASC is recruited via a PYD-PYD interaction

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Staphylococcus aureus
Locations in the PathwayBrowser
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NLRP3 interacts with ASC (Manji et al. 2003) via their PYD domains (Dowds et al. 2004). NLRP3 oligomerization leads to PYD domain clustering which is believed to facilitate the interaction of NLRP3 with the PYD domain of ASC (Schroder & Tschopp, 2010).

Literature References
PubMed ID Title Journal Year
12615073 Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product

Dowds, TA, Masumoto, J, Chen, FF, Ogura, Y, Inohara, N, Nunez, G

Biochem Biophys Res Commun 2003
11786556 PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

Manji, GA, Wang, L, Geddes, BJ, Brown, M, Merriam, S, Al-Garawi, A, Mak, S, Lora, JM, Briskin, M, Jurman, M, Cao, J, DiStefano, PS, Bertin, J

J Biol Chem 2002
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