TXNIP binds NLRP3

Stable Identifier
R-HSA-1250272
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome.

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