TXNIP binds NLRP3

Stable Identifier
R-HSA-1250272
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Reaction
Species
Homo sapiens
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Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome.

Literature References
PubMed ID Title Journal Year
20023662 Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R, Tardivel, A, Thorens, B, Choi, I, Tschopp, J

Nat Immunol 2010
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