NTPDase1 hydrolyzes nucleoside triphosphates

Stable Identifier
Reaction [transition]
Homo sapiens
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NTPDase1 (CD39) is a plasma membrane-bound ectonucleotidase encoded by the ENTPD1 gene that hydrolyzes extracellular NTPs to NMPs, via corresponding NDP intermediates (Lemmens et al. 2000, Kukulski et al. 2005). NTPDase1 is expressed on endothelial cells, smooth muscle cells and most leukocytes. The vascular endothelial NTPDase1 regulates platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjoyji et al. 1999). In mice, NTPDase1 is expressed at the surface of epidermal dendritic cells (Langerhans cells) and is involved in regulation of immune response to skin irritants (Mizumoto et al. 2002). NTPDase1 expressed in vascular smooth muscle cells regulates vasomotion (Kauffenstein et al. 2010, reviewed by Kukulski et al. 2011). In regulatory T lymphocytes (Tregs) and other leukocytes NTPDase1 regulates inflammatory processes (Deaglio et al. 2007).

Literature References
PubMed ID Title Journal Year
8955160 Identification and characterization of CD39/vascular ATP diphosphohydrolase

Anrather, J, Robson, SC, Sévigny, J, Beaudoin, AR, Siegel, JB, Koziak, K, Bach, FH, Kaczmarek, E

J Biol Chem 1996
18404504 Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8

Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF

Purinergic Signal. 2005
21586362 Impact of ectoenzymes on p2 and p1 receptor signaling

Sévigny, J, Kukulski, F, Lévesque, SA

Adv. Pharmacol. 2011
11927941 CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness

Sévigny, J, Takashima, A, Kumamoto, T, Robson, SC, Mizumoto, N, Matsue, H, Enjyoji, K

Nat. Med. 2002
19640930 NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse

Kauffenstein, G, Sévigny, J, Thorin-Trescases, N, Robaye, B, D'Orléans-Juste, P, Drouin, A, Marceau, F, Bachelard, H, Thorin, E

Cardiovasc. Res. 2010
10470077 Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

Lech, M, Frenette, PS, Csizmadia, E, Rosenberg, RD, Imai, M, Lin, Y, Enjyoji, K, Robson, SC, Wagner, DD, Sévigny, J, Edelberg, JM, Esch, JS, Christie, PD, Rayburn, H, Beeler, DL

Nat. Med. 1999
10866813 Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1

Vanduffel, L, Beaudoin, AR, Benrezzak, O, Sévigny, J, Lemmens, R, Kittel, A

Eur. J. Biochem. 2000
17502665 Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Chen, JF, Strom, TB, Friedman, D, Dwyer, KM, Deaglio, S, Usheva, A, Oukka, M, Enjyoji, K, Gao, W, Robson, SC, Erat, A, Kuchroo, VK, Linden, J

J. Exp. Med. 2007
Catalyst Activity

nucleoside-triphosphatase activity of NTPDase1:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cross References
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