Reactome | NTPDase1 hydrolyzes nucleoside triphosphates

NTPDase1 hydrolyzes nucleoside triphosphates

Stable Identifier

R-HSA-8850846

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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NTPDase1 hydrolyzes nucleoside triphosphates

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NTPDase1 (CD39) is a plasma membrane-bound ectonucleotidase encoded by the ENTPD1 gene that hydrolyzes extracellular NTPs to NMPs, via corresponding NDP intermediates (Lemmens et al. 2000, Kukulski et al. 2005). NTPDase1 is expressed on endothelial cells, smooth muscle cells and most leukocytes. The vascular endothelial NTPDase1 regulates platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjoyji et al. 1999). In mice, NTPDase1 is expressed at the surface of epidermal dendritic cells (Langerhans cells) and is involved in regulation of immune response to skin irritants (Mizumoto et al. 2002). NTPDase1 expressed in vascular smooth muscle cells regulates vasomotion (Kauffenstein et al. 2010, reviewed by Kukulski et al. 2011). In regulatory T lymphocytes (Tregs) and other leukocytes NTPDase1 regulates inflammatory processes (Deaglio et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
8955160	Identification and characterization of CD39/vascular ATP diphosphohydrolase Anrather, J, Robson, SC, Sévigny, J, Beaudoin, AR, Siegel, JB, Koziak, K, Bach, FH, Kaczmarek, E	J Biol Chem	1996
18404504	Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF	Purinergic Signal.	2005
21586362	Impact of ectoenzymes on p2 and p1 receptor signaling Sévigny, J, Kukulski, F, Lévesque, SA	Adv. Pharmacol.	2011
11927941	CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness Sévigny, J, Takashima, A, Kumamoto, T, Robson, SC, Mizumoto, N, Matsue, H, Enjyoji, K	Nat. Med.	2002
19640930	NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse Kauffenstein, G, Sévigny, J, Thorin-Trescases, N, Robaye, B, D'Orléans-Juste, P, Drouin, A, Marceau, F, Bachelard, H, Thorin, E	Cardiovasc. Res.	2010
10470077	Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation Lech, M, Frenette, PS, Csizmadia, E, Rosenberg, RD, Imai, M, Lin, Y, Enjyoji, K, Robson, SC, Wagner, DD, Sévigny, J, Edelberg, JM, Esch, JS, Christie, PD, Rayburn, H, Beeler, DL	Nat. Med.	1999
10866813	Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1 Vanduffel, L, Beaudoin, AR, Benrezzak, O, Sévigny, J, Lemmens, R, Kittel, A	Eur. J. Biochem.	2000
17502665	Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression Chen, JF, Strom, TB, Friedman, D, Dwyer, KM, Deaglio, S, Usheva, A, Oukka, M, Enjyoji, K, Gao, W, Robson, SC, Erat, A, Kuchroo, VK, Linden, J	J. Exp. Med.	2007