Reactome | CTSG cleaves CASP1(1-404)

CTSG cleaves CASP1(1-404)

Stable Identifier

R-HSA-448678

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase-1 precursor is cleaved releasing p10 and p20 subunits

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)

General

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SVG | | PPTX | SBGN

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Caspase 1 is expressed as a precursor that is cleaved to generate the p10 and p20 subunits that subsequently form the active tetramer.

Literature References

PubMed ID	Title	Journal	Year
8044845	Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer Hackett, MC, Dang, LC, Franklin, S, Ghayur, T, Ferenz, CR, Walker, NP, Bump, NJ, Brady, KD, Talanian, RV, Hammill, LD	Cell	1994