CTSG cleaves CASP1(1-404)

Stable Identifier
R-HSA-448678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Caspase-1 precursor is cleaved releasing p10 and p20 subunits
Locations in the PathwayBrowser
General
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Caspase 1 is expressed as a precursor that is cleaved to generate the p10 and p20 subunits that subsequently form the active tetramer.

Literature References
PubMed ID Title Journal Year
8044845 Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

Walker, NP, Talanian, RV, Brady, KD, Dang, LC, Bump, NJ, Ferenz, CR, Franklin, S, Ghayur, T, Hackett, MC, Hammill, LD

Cell 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptidase activity of CTSG [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created