CTSG cleaves CASP1(1-404)

Stable Identifier
R-HSA-448678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase-1 precursor is cleaved releasing p10 and p20 subunits
ReviewStatus
5/5
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CTSG cleaves CASP1(1-404)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase 1 is expressed as a precursor that is cleaved to generate the p10 and p20 subunits that subsequently form the active tetramer.
Literature References
PubMed ID Title Journal Year
8044845 Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

Hackett, MC, Dang, LC, Franklin, S, Ghayur, T, Ferenz, CR, Walker, NP, Bump, NJ, Brady, KD, Talanian, RV, Hammill, LD

Cell 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptidase activity of CTSG [cytosol]

Physical Entity
CTSG [cytosol] (Homo sapiens)
Activity
peptidase activity (GO:0008233)
Orthologous Events
CTSG cleaves CASP1(1-404) (Bos taurus)
CTSG cleaves CASP1(1-404) (Canis familiaris)
CTSG cleaves CASP1(1-404) (Mus musculus)
CTSG cleaves CASP1(1-404) (Rattus norvegicus)
CTSG cleaves CASP1(1-404) (Sus scrofa)
CTSG cleaves CASP1(1-404) (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-09-06)
Created
Jupe, S  (2009-11-25)
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