It has been shown that anaphylatoxin C3a binding to its receptor C3AR1 indirectly activates the proinflammatory cytokine IL1β (Laudisi, 2013 and Asgari, 2013). Asgari et al. suggest a mechanism; after the binding of C3a to C3AR1, ATP release is promoted from the cytosol to the extracellular space through an unknown channel. From here, ATP binding to P2X purinoceptors activates the inflammasome that results in the production of IL1β (Asgari 2013).
Morgan, BP, Evrard, M, Sivasankar, B, Laudisi, F, Hughes, TR, Mandriani, B, Spreafico, R, Mortellaro, A, Kandasamy, M
Sacks, SS, Cook, HT, Le Friec, G, Asgari, E, Kemper, C, Yamamoto, H, Perucha, E, Köhl, J
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