Pyrin binds ASC

Stable Identifier
R-HSA-877361
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003).

Literature References
PubMed ID Title Journal Year
12615073 Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product

Dowds, TA, Masumoto, J, Chen, FF, Ogura, Y, Inohara, N, Nunez, G

Biochem Biophys Res Commun 2003
11498534 Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

Richards, N, Schaner, P, Diaz, A, Stuckey, J, Shelden, E, Wadhwa, A, Gumucio, DL

J Biol Chem 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created