TXNIP binds reduced thioredoxin

Stable Identifier
R-HSA-1250264
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TXNIP interacts with the redox-active domain of thioredoxin (TRX) and is believed to act as an oxidative stress mediator by inhibiting TRX activity or by limiting its bioavailability (Nishiyama et al. 1999, Liyanage et al. 2007).

Literature References
PubMed ID Title Journal Year
17603038 Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)

Liyanage, NP, Fernando, MR, Lou, MF

Exp Eye Res 2007
Participants
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Orthologous Events
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