Expression of NLRP3 gene

Stable Identifier
R-HSA-9603905
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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Expression of NLRP3 gene
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Two signals are required for NLRP3 inflammasome activation. Signal 1, also known as the priming signal, is mediated by microbial ligands recognised by TLRs or cytokines such as TNF-α which activate the NF-κB pathway, leading to upregulation of pro-IL-1β and NLRP3 protein levels (Bauernfeind et al. 2009, Jo et al. 2016).

Literature References
PubMed ID Title Journal Year
26549800 Molecular mechanisms regulating NLRP3 inflammasome activation

Jo, EK, Kim, JK, Shin, DM, Sasakawa, C

Cell. Mol. Immunol. 2016
19570822 Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

Bauernfeind, FG, Horvath, G, Stutz, A, Alnemri, ES, MacDonald, K, Speert, D, Fernandes-Alnemri, T, Wu, J, Monks, BG, Fitzgerald, KA, Hornung, V, Latz, E

J Immunol 2009
Participants
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Output
Participant Of
hasEvent
This event is regulated
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Authored
Jassal, B  (2018-03-28)
Reviewed
Jo, EK  (2018-03-29)
Created
Jassal, B  (2018-03-28)