Expression of NLRP3 gene

Stable Identifier
R-HSA-9603905
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of NLRP3 gene
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Two signals are required for NLRP3 inflammasome activation. Signal 1, also known as the priming signal, is mediated by microbial ligands recognised by TLRs or cytokines such as TNF-α which activate the NF-κB pathway, leading to upregulation of pro-IL-1β and NLRP3 protein levels (Bauernfeind et al. 2009, Jo et al. 2016). In the absence of TLR agonist 'priming', inflammasome dependent caspase-1 activation is observed but IL-1 beta secretion is minimal. This is primarily because pro-IL1 beta is not expressed in most cells until stimulated by proinflammatory signals such as TNF or LPS that activate NFkappaB. NFkappaB induces expression of pro-IL1beta that can be activated by caspase-1.
Literature References
PubMed ID Title Journal Year
19570822 Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

Bauernfeind, FG, Horvath, G, Stutz, A, Alnemri, ES, MacDonald, K, Speert, D, Fernandes-Alnemri, T, Wu, J, Monks, BG, Fitzgerald, KA, Hornung, V, Latz, E

J Immunol 2009
26549800 Molecular mechanisms regulating NLRP3 inflammasome activation

Jo, EK, Kim, JK, Shin, DM, Sasakawa, C

Cell. Mol. Immunol. 2016
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This event is regulated
Positively by
Regulator
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Authored
Jassal, B  (2018-03-28)
Reviewed
Jo, EK  (2018-03-29)
Created
Jassal, B  (2018-03-28)
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