Expression of NLRP3 gene

Stable Identifier
R-HSA-9603905
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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Two signals are required for NLRP3 inflammasome activation. Signal 1, also known as the priming signal, is mediated by microbial ligands recognised by TLRs or cytokines such as TNF-α which activate the NF-κB pathway, leading to upregulation of pro-IL-1β and NLRP3 protein levels (Bauernfeind et al. 2009, Jo et al. 2016). In the absence of TLR agonist 'priming', inflammasome dependent caspase-1 activation is observed but IL-1 beta secretion is minimal. This is primarily because pro-IL1 beta is not expressed in most cells until stimulated by proinflammatory signals such as TNF or LPS that activate NFkappaB. NFkappaB induces expression of pro-IL1beta that can be activated by caspase-1.

Literature References
PubMed ID Title Journal Year
19570822 Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

Horvath, G, Fitzgerald, KA, Stutz, A, Wu, J, Bauernfeind, FG, Latz, E, Hornung, V, Speert, D, Monks, BG, MacDonald, K, Alnemri, ES, Fernandes-Alnemri, T

J Immunol 2009
26549800 Molecular mechanisms regulating NLRP3 inflammasome activation

Jo, EK, Shin, DM, Sasakawa, C, Kim, JK

Cell. Mol. Immunol. 2016
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