C3a receptor binds anaphylatoxin C3a

Stable Identifier
R-HSA-444647
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The complement component 3a receptor (C3AR) binds C3a, a 77-amino acid anaphylatoxin generated after proteolytic cleavage of C3 and C5 in response to complement activation. C3a is involved in a variety of inflammatory responses including chemotaxis and activation of granulocytes, mast cells and macrophages (Peng et al. 200, Klos et al. 2009).

Literature References
PubMed ID Title Journal Year
8702752 Molecular cloning and characterization of the human anaphylatoxin C3a receptor

Ames, RS, Li, Y, Sarau, HM, Nuthulaganti, P, Foley, JJ, Ellis, C, Zeng, Z, Su, K, Jurewicz, AJ, Hertzberg, RP, Bergsma, DJ, Kumar, C

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
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Reviewed
Created