Reactome | C3a receptor binds anaphylatoxin C3a

C3a receptor binds anaphylatoxin C3a

Stable Identifier

R-HSA-444647

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        C3a receptor binds anaphylatoxin C3a (Homo sapiens)

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The complement component 3a receptor (C3AR) binds C3a, a 77-amino acid anaphylatoxin generated after proteolytic cleavage of C3 and C5 in response to complement activation. C3a is involved in a variety of inflammatory responses including chemotaxis and activation of granulocytes, mast cells and macrophages (Peng et al. 200, Klos et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
8702752	Molecular cloning and characterization of the human anaphylatoxin C3a receptor Ames, RS, Li, Y, Sarau, HM, Nuthulaganti, P, Foley, JJ, Ellis, C, Zeng, Z, Su, K, Jurewicz, AJ, Hertzberg, RP, Bergsma, DJ, Kumar, C	J Biol Chem	1996