SGT1 binds HSP90

Stable Identifier
R-HSA-874087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SGT1 binds HSP90
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The ubiquitin ligase–associated protein SGT1 (SUGT1) has two putative HSP90 binding domains, a tetratricopeptide repeat and a p23-like CHORD and Sgt1 (CS) domain. The CS domain of human SGT1 physically interacts with HSP90. SGT1 and related proteins are believed to recruit heat shock proteins to multiprotein assemblies (Lee et al. 2004).
Literature References
PubMed ID Title Journal Year
14761955 Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain

Chazin, WJ, Nowotny, M, Kuznicki, J, Michowski, W, Lee, YT, Jacob, J

J Biol Chem 2004
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Orthologous Events
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SGT1 binds HSP90 (Gallus gallus)
SGT1 binds HSP90 (Mus musculus)
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SGT1 binds HSP90 (Saccharomyces cerevisiae)
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SGT1 binds HSP90 (Sus scrofa)
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Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-06-10)
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