TXNIP is released from oxidized thioredoxin

Stable Identifier
R-HSA-1250253
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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ROS induce the dissociation of TXNIP from thioredoxin, freeing TXNIP to subsequently bind NLRP3 and bring about activation of the NLRP3 inflammasome (Zhou et al. 2010).

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