Reactome | TXNIP is released from oxidized thioredoxin

TXNIP is released from oxidized thioredoxin

Stable Identifier

R-HSA-1250253

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        TXNIP is released from oxidized thioredoxin (Homo sapiens)

General

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TXNIP is released from oxidized thioredoxin

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ROS induce the dissociation of TXNIP from thioredoxin, freeing TXNIP to subsequently bind NLRP3 and bring about activation of the NLRP3 inflammasome (Zhou et al. 2010).

Participants

Input

Oxidized thioredoxin:TXNIP [cytosol] (Homo sapiens)

Output

Participates

as an event of

Inferred From

Txnip is released from oxidized thioredoxin (Mus musculus)

Authored

Jupe, S (2011-04-28)

Reviewed

Kufer, TA (2011-04-28)

Rittinger, K (2011-06-06)

Wong, E (2011-06-06)

Created

Jupe, S (2011-04-15)

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