The CARD domain of ASC recruits Procaspase-1

Stable Identifier
R-HSA-844612
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Staphylococcus aureus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Procaspase-1 is recruited via a CARD-CARD interaction with ASC. This creates procaspase-1 clustering which is believed to stimulate procaspase-1 autocleavage, generating the p10/p20 fragments that assemble into the active capsase-1 tetramer (Schroder & Tschopp, 2010).

Literature References
PubMed ID Title Journal Year
12191486 The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

Martinon, F, Burns, K, Tschopp, J

Mol Cell 2002
11967258 The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

Srinivasula, SM, Poyet, JL, Razmara, M, Datta, P, Zhang, Z, Alnemri, ES

J Biol Chem 2002
Participants
Participant Of
Authored
Reviewed
Created