PYCARD recruits procaspase-1 via CARD

Stable Identifier
R-HSA-844612
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Staphylococcus aureus
Compartment
cytosol
Synonyms
The CARD domain of ASC recruits Procaspase-1
ReviewStatus
5/5
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PYCARD recruits procaspase-1 via CARD
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Procaspase-1 is recruited via a CARD-CARD interaction with ASC. This creates procaspase-1 clustering which is believed to stimulate procaspase-1 autocleavage, generating the p10/p20 fragments that assemble into the active capsase-1 tetramer (Schroder & Tschopp, 2010).
Literature References
PubMed ID Title Journal Year
11967258 The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

Srinivasula, SM, Poyet, JL, Razmara, M, Datta, P, Zhang, Z, Alnemri, ES

J Biol Chem 2002
12191486 The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

Martinon, F, Burns, K, Tschopp, J

Mol Cell 2002
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Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-28)
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