Reactome | SEC13 [lysosomal membrane]

SEC13 [lysosomal membrane]

Stable Identifier

R-HSA-9638246

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

fullName evidence="28"Protein SEC13 homolog, SEC13_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55735 SEC13

Gene Names

SEC13, D3S1231E, SEC13A, SEC13L1, SEC13R

Chain

initiator methionine:1, chain:2-322

Reference Genes

BioGPS Gene:6396 SEC13

COSMIC (genes):SEC13 SEC13

CTD Gene:6396 SEC13

dbSNP Gene:6396 SEC13

ENSEMBL:ENSG00000157020 SEC13

ENSEMBL:ENSG00000157020.18 SEC13

HGNC:10697 SEC13

KEGG Gene (Homo sapiens):6396 SEC13

Monarch:6396 SEC13

NCBI Gene:6396 SEC13

OMIM:600152 SEC13

UCSC:P55735 SEC13

Reference Transcript

Other Identifiers

11716188_s_at

11716189_x_at

11756179_x_at

16950686

207707_PM_s_at

207707_s_at

2662662

2662663

2662664

2662665

2662667

2662668

2662669

2662671

2662678

2662679

2662683

2662685

2662687

2662688

2662694

2662695

33422_at

33423_g_at

6396

8085300

A_23_P29555

A_24_P214506

A_33_P3210909

GE83163

GO:0000776

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005764

GO:0005765

GO:0005773

GO:0005783

GO:0005789

GO:0005829

GO:0006606

GO:0006886

GO:0006913

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0023052

GO:0030127

GO:0031080

GO:0031410

GO:0032008

GO:0032527

GO:0042802

GO:0043226

GO:0043231

GO:0051028

GO:0061024

GO:0061700

GO:0070062

GO:0090110

GO:0090114

GO:1904262

GO:1904263

HMNXSV003016068

HMNXSV003035653

HMNXSV003039589

L09260_at

PH_hs_0012668

TC03002801.hg

TC03002802.hg

g13491163_3p_a_at

Participates

as a component of

GATOR2 [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

SEC13 [endoplasmic reticulum membrane]

SEC13 [cytosol]

SEC13 [ER to Golgi transport vesicle membrane]

Inferred To

SEC13 [lysosomal membrane] (Bos taurus)

SEC13 [lysosomal membrane] (Canis familiaris)

SEC13 [lysosomal membrane] (Danio rerio)

SEC13 [lysosomal membrane] (Gallus gallus)

SEC13 [lysosomal membrane] (Sus scrofa)

Sec13 [lysosomal membrane] (Mus musculus)

Sec13 [lysosomal membrane] (Rattus norvegicus)

sec13 [lysosomal membrane] (Dictyostelium discoideum)

sec13 [lysosomal membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001129498.1, XP_005265436.1, XP_016862508.1, NP_001129704.1, NP_899195.1, NP_109598.2

OpenTargets

ENSG00000157020

HPA

ENSG00000157020-SEC13

GeneCards

P55735

Ensembl

ENSP00000312122, ENST00000397109, ENSP00000373312, ENSG00000157020, ENSP00000380298, ENSP00000336566, ENST00000383801, ENST00000350697, ENST00000337354

PRO

P55735

Pharos - Targets

P55735

PDB

3BG1, 7R5J, 7PEQ, 7UHY, 3BG0, 7R5K, 5A9Q

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49687	1	NUP145 [cytosol] (R-SCE-376247)	0.698	15
UniProt:Q96JE7-2 SEC16B			0.666	6
UniProt:Q8NFH4 NUP37	2	NUP37 [nuclear envelope] (R-HSA-157745) NUP37 [cytosol] (R-HSA-376237)	0.659	3
UniProt:Q9NXC5 MIOS	1	MIOS [lysosomal membrane] (R-HSA-9638223)	0.643	3
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012)	0.635	3
UniProt:Q96EE3 SEH1L	1	SEH1L [lysosomal membrane] (R-HSA-9638217)	0.621	3
UniProt:Q8BH74	2	Nup107 [nuclear envelope] (R-MMU-157717) Nup107 [cytosol] (R-MMU-376241)	0.564	2
UniProt:Q9BW27 NUP85	2	NUP85 [nuclear envelope] (R-HSA-157741) NUP85 [cytosol] (R-HSA-376238)	0.564	2
UniProt:Q6PFD9	9	phospho-Nup98 [cytosol] (R-MMU-2990915) phospho-Nup98 [cytosol] (R-MMU-2990893) phospho-Nup98 [nucleoplasm] (R-MMU-2990884) phospho-Nup98 [nucleoplasm] (R-MMU-2990914) phospho-Nup98 [nuclear envelope] (R-MMU-2990895) phospho-Nup98 [nuclear envelope] (R-MMU-2990916) Nup98 [nuclear envelope] (R-MMU-2990912) Nup98 [nuclear envelope] (R-MMU-157723) Nup98 [cytosol] (R-MMU-376247)	0.564	2
UniProt:O00463 TRAF5			0.556	3
UniProt:Q96S15 WDR24	1	WDR24 [lysosomal membrane] (R-HSA-9638247)	0.527	2
UniProt:P57740 NUP107	2	NUP107 [nuclear envelope] (R-HSA-157717) NUP107 [cytosol] (R-HSA-376241)	0.527	2
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.527	2
UniProt:Q6PJI9 WDR59	1	WDR59 [lysosomal membrane] (R-HSA-9638236)	0.527	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.508	2
UniProt:P37198 NUP62	2	NUP62 [cytosol] (R-HSA-9634226) NUP62 [nuclear envelope] (R-HSA-157713)	0.488	2

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