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SEC13 [lysosomal membrane]
Stable Identifier
R-HSA-9638246
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
fullName evidence="28"Protein SEC13 homolog, SEC13_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
SEC13 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55735 SEC13
Gene Names
SEC13, D3S1231E, SEC13A, SEC13L1, SEC13R
Chain
initiator methionine:, chain:2-322
Reference Genes
BioGPS Gene:6396 SEC13
COSMIC (genes):SEC13 SEC13
CTD Gene:6396 SEC13
dbSNP Gene:6396 SEC13
ENSEMBL:ENSG00000157020 SEC13
ENSEMBL_homo_sapiens_GENE:ENSG00000157020.18 SEC13
HGNC:10697 SEC13
KEGG Gene (Homo sapiens):6396 SEC13
Monarch:6396 SEC13
NCBI Gene:6396 SEC13
OMIM:600152 SEC13
UCSC:P55735 SEC13
Reference Transcript
RefSeq:NM_030673.3 SEC13
RefSeq:XM_017007019.1 SEC13
RefSeq:NM_001136026.2 SEC13
RefSeq:NM_183352.2 SEC13
RefSeq:NM_001136232.2 SEC13
RefSeq:XM_005265379.2 SEC13
Other Identifiers
11716188_s_at
11716189_x_at
11756179_x_at
16950686
207707_PM_s_at
207707_s_at
2662662
2662663
2662664
2662665
2662667
2662668
2662669
2662671
2662678
2662679
2662683
2662685
2662687
2662688
2662694
2662695
33422_at
33423_g_at
6396
8085300
A_23_P29555
A_24_P214506
A_33_P3210909
GE83163
GO:0000776
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005694
GO:0005764
GO:0005765
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0006606
GO:0006886
GO:0006913
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0023052
GO:0030127
GO:0031080
GO:0031410
GO:0031669
GO:0032008
GO:0032527
GO:0042802
GO:0043226
GO:0043231
GO:0051028
GO:0061024
GO:0061700
GO:0070062
GO:0090110
GO:0090114
GO:1904262
GO:1904263
HMNXSV003016068
HMNXSV003035653
HMNXSV003039589
L09260_at
PH_hs_0012668
TC03002801.hg
TC03002802.hg
g13491163_3p_a_at
Participates
as a component of
GATOR2 [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
SEC13 [ER to Golgi transport vesicle membrane]
SEC13 [cytosol]
SEC13 [endoplasmic reticulum membrane]
Inferred To
SEC13 [lysosomal membrane]
(Bos taurus)
SEC13 [lysosomal membrane]
(Canis familiaris)
SEC13 [lysosomal membrane]
(Gallus gallus)
SEC13 [lysosomal membrane]
(Sus scrofa)
Sec13 [lysosomal membrane]
(Mus musculus)
Sec13 [lysosomal membrane]
(Rattus norvegicus)
sec13 [lysosomal membrane]
(Dictyostelium discoideum)
sec13 [lysosomal membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_899195.1
,
NP_001129704.1
,
XP_005265436.1
,
NP_001129498.1
,
NP_109598.2
,
XP_016862508.1
OpenTargets
ENSG00000157020
GeneCards
P55735
HPA
ENSG00000157020-SEC13
Ensembl
ENST00000397109
,
ENST00000337354
,
ENST00000350697
,
ENSP00000336566
,
ENSG00000157020
,
ENST00000383801
,
ENSP00000312122
,
ENSP00000380298
,
ENSP00000373312
PRO
P55735
Pharos - Targets
P55735
PDB
7R5J
,
7PEQ
,
3BG0
,
5A9Q
,
7UHY
,
7R5K
,
3BG1
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NFH4 NUP37
2
NUP37 [nuclear envelope]
(R-HSA-157745)
NUP37 [cytosol]
(R-HSA-376237)
0.798
8
UniProt:Q9NXC5 MIOS
1
MIOS [lysosomal membrane]
(R-HSA-9638223)
0.788
8
UniProt:Q96EE3 SEH1L
1
SEH1L [lysosomal membrane]
(R-HSA-9638217)
0.775
8
UniProt:Q9BW27 NUP85
2
NUP85 [nuclear envelope]
(R-HSA-157741)
NUP85 [cytosol]
(R-HSA-376238)
0.744
7
UniProt:O94979 SEC31A
5
SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713475)
SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713478)
SEC31A [ER to Golgi transport vesicle membrane]
(R-HSA-204010)
SEC31A [endoplasmic reticulum membrane]
(R-HSA-204000)
SEC31A [cytosol]
(R-HSA-203983)
0.734
7
UniProt:Q96S15 WDR24
1
WDR24 [lysosomal membrane]
(R-HSA-9638247)
0.725
7
UniProt:P57740 NUP107
2
NUP107 [nuclear envelope]
(R-HSA-157717)
NUP107 [cytosol]
(R-HSA-376241)
0.725
7
UniProt:Q6PJI9 WDR59
1
WDR59 [lysosomal membrane]
(R-HSA-9638236)
0.725
7
UniProt:P49687 NU145
0.698
15
UniProt:Q96JE7-2 SEC16B
0.666
6
UniProt:Q12769 NUP160
2
NUP160 [nuclear envelope]
(R-HSA-157721)
NUP160 [cytosol]
(R-HSA-376253)
0.643
6
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.643
5
UniProt:Q8NFH3 NUP43
2
NUP43 [nuclear envelope]
(R-HSA-157739)
NUP43 [cytosol]
(R-HSA-376243)
0.643
5
UniProt:Q8WUM0 NUP133
2
NUP133 [nuclear envelope]
(R-HSA-157743)
NUP133 [cytosol]
(R-HSA-376251)
0.643
6
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.643
3
UniProt:Q15436 SEC23A
4
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
0.636
3
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
SEC13 [cytosol]
(R-HSA-203981)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
0.635
3
UniProt:Q6PFD9
9
phospho-Nup98 [cytosol]
(R-MMU-2990915)
phospho-Nup98 [cytosol]
(R-MMU-2990893)
phospho-Nup98 [nucleoplasm]
(R-MMU-2990884)
phospho-Nup98 [nucleoplasm]
(R-MMU-2990914)
phospho-Nup98 [nuclear envelope]
(R-MMU-2990895)
phospho-Nup98 [nuclear envelope]
(R-MMU-2990916)
Nup98 [nuclear envelope]
(R-MMU-2990912)
Nup98 [nuclear envelope]
(R-MMU-157723)
Nup98 [cytosol]
(R-MMU-376247)
0.564
2
UniProt:Q8BH74
2
Nup107 [nuclear envelope]
(R-MMU-157717)
Nup107 [cytosol]
(R-MMU-376241)
0.564
2
UniProt:O00463 TRAF5
0.556
3
UniProt:Q96JE7 SEC16B
1
SEC16B [cytosol]
(R-HSA-5685731)
0.547
3
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.527
4
UniProt:P11274 BCR
4
BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838979)
p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839041)
BCR(1-584)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604524)
BCR [cytosol]
(R-HSA-195200)
0.527
4
UniProt:P09497 CLTB
5
CLTB [cytosol]
(R-HSA-8856819)
CLTB [trans-Golgi network membrane]
(R-HSA-5333645)
CLTB [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138428)
CLTB [lysosomal membrane]
(R-HSA-2980616)
CLTB [plasma membrane]
(R-HSA-2980617)
0.527
2
UniProt:Q96EA4 SPDL1
1
SPDL1 [cytosol]
(R-HSA-377733)
0.527
3
UniProt:P52948 NUP98
0.527
5
UniProt:Q03154 ACY1
6
ACY1 R393H [cytosol]
(R-HSA-5579106)
ACY1 E233D [cytosol]
(R-HSA-5579040)
ACY1 R197W [cytosol]
(R-HSA-5579041)
ACY1 [cytosol]
(R-HSA-5433075)
ACY1 R353C [cytosol]
(R-HSA-5579111)
ACY1 P369Hfs*47 [cytosol]
(R-HSA-5579105)
0.527
5
UniProt:Q92734 TFG
7
TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702019)
TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702038)
TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]
(R-HSA-9702029)
TFG(1-193)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699887)
TFG(1-138)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699874)
TFG(1-240)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699806)
TFG [cytosol]
(R-HSA-5688159)
0.527
2
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.527
3
UniProt:Q96BP3 PPWD1
1
PPWD1 [nucleoplasm]
(R-HSA-8867893)
0.527
2
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.527
2
UniProt:P37198 NUP62
2
NUP62 [cytosol]
(R-HSA-9634226)
NUP62 [nuclear envelope]
(R-HSA-157713)
0.488
2
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