Reactome | SEC16B [cytosol]

SEC16B [cytosol]

Stable Identifier

R-HSA-5685731

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96JE7 SEC16B

Gene Names

SEC16B, KIAA1928, LZTR2, RGPR, SEC16S

Chain

chain:1-1060

Reference Genes

BioGPS Gene:89866 SEC16B

COSMIC (genes):SEC16B SEC16B

CTD Gene:89866 SEC16B

dbSNP Gene:89866 SEC16B

ENSEMBL:ENSG00000120341.19 SEC16B

HGNC:30301 SEC16B

KEGG Gene (Homo sapiens):89866 SEC16B

Monarch:89866 SEC16B

NCBI Gene:89866 SEC16B

OMIM:612855 SEC16B

UCSC:Q96JE7 SEC16B

Reference Transcript

RefSeq:NM_033127.2 SEC16B

Other Identifiers

0002230609

111240474

11750653_a_at

11759406_a_at

1552880_PM_at

1552880_at

1564423_PM_a_at

1564423_a_at

16696731

228150_PM_at

228150_at

2445646

2445647

2445648

2445649

2445650

2445651

2445652

2445654

2445655

2445656

2445657

2445658

2445661

2445662

2445663

2445666

2445669

2445670

2445671

2445678

2445679

2445682

2445685

2445687

2445688

2445690

2445692

2445694

2445696

2445698

2445704

2445706

2445707

2445708

2445710

47539_at

7922550

89866

A_33_P3418218

GE83614

GO:0000139

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006914

GO:0007029

GO:0007030

GO:0007031

GO:0010628

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0016559

GO:0031410

GO:0043226

GO:0043231

GO:0046907

GO:0048208

GO:0061024

GO:0065003

GO:0070863

GO:0070971

GO:0070973

HMNXSV003013599

Hs.293650.0.A1_3p_at

Hs.293650.0.A1_3p_s_at

Hs2.293650.1.S1_3p_at

Hs2.293650.5.S1_3p_a_at

ILMN_1748719

PH_hs_0024032

Participates

as a component of

SEC16A:SEC16B [cytosol] (Homo sapiens)

Inferred To

sec-16a.2 [cytosol] (Caenorhabditis elegans)

Sec16b [cytosol] (Mus musculus)

Sec16b [cytosol] (Rattus norvegicus)

Sec16 [cytosol] (Drosophila melanogaster)

sec16b [cytosol] (Xenopus tropicalis)

sec16 [cytosol] (Schizosaccharomyces pombe)

wimA [cytosol] (Dictyostelium discoideum)

SEC16B [cytosol] (Bos taurus)

SEC16B [cytosol] (Canis familiaris)

SEC16B [cytosol] (Danio rerio)

SEC16B [cytosol] (Gallus gallus)

SEC16B [cytosol] (Sus scrofa)

SEC16 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_149118.2

OpenTargets

ENSG00000120341

GeneCards

Q96JE7

HPA

ENSG00000120341-SEC16B

Ensembl

ENST00000308284, ENSP00000308339, ENSG00000120341

PRO

Q96JE7

Pharos - Targets

Q96JE7

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