Reactome | SEC16B [cytosol]

SEC16B [cytosol]

Stable Identifier

R-HSA-5685731

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96JE7 SEC16B

Gene Names

SEC16B, KIAA1928, LZTR2, RGPR, SEC16S

Chain

chain:1-1060

Reference Genes

BioGPS Gene:89866 SEC16B

COSMIC (genes):SEC16B SEC16B

CTD Gene:89866 SEC16B

dbSNP Gene:89866 SEC16B

ENSEMBL:ENSG00000120341 SEC16B

HGNC:30301 SEC16B

KEGG:hsa:89866 SEC16B

Monarch:89866 SEC16B

NCBI Gene:89866 SEC16B

OMIM:612855 SEC16B

UCSC:Q96JE7 SEC16B

Reference Transcript

Participates

as a component of

SEC16A:SEC16B [cytosol] (Homo sapiens)

Inferred To

sec-16a.2 [cytosol] (Caenorhabditis elegans)

Sec16b [cytosol] (Mus musculus)

Sec16b [cytosol] (Rattus norvegicus)

Ghost homologue of SEC16B [cytosol] (Plasmodium falciparum)

Sec16 [cytosol] (Drosophila melanogaster)

Homologues of SEC16B [cytosol] (Caenorhabditis elegans)

sec16b [cytosol] (Xenopus tropicalis)

sec16 [cytosol] (Schizosaccharomyces pombe)

wimA [cytosol] (Dictyostelium discoideum)

sec-16A.1 [cytosol] (Caenorhabditis elegans)

SEC16B [cytosol] (Bos taurus)

SEC16B [cytosol] (Canis familiaris)

SEC16B [cytosol] (Gallus gallus)

SEC16B [cytosol] (Sus scrofa)

SEC16 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001377762.1, NP_149118.2

ENSEMBL

ENST00000308284, ENSG00000120341, ENSP00000308339

OpenTargets

ENSG00000120341

GeneCards

SEC16B

HPA

ENSG00000120341-SEC16B

PRO

Q96JE7

Pharos - Targets

Q96JE7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.547	3