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MIOS [lysosomal membrane]
Stable Identifier
R-HSA-9638223
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
fullName evidence="14"GATOR complex protein MIOS, MIO_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
MIOS [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NXC5 MIOS
Gene Names
MIOS
Chain
chain:1-875
Reference Genes
BioGPS Gene:54468 MIOS
COSMIC (genes):MIOS MIOS
CTD Gene:54468 MIOS
dbSNP Gene:54468 MIOS
ENSEMBL:ENSG00000164654 MIOS
HGNC:21905 MIOS
Monarch:54468 MIOS
NCBI Gene:54468 MIOS
OMIM:615359 MIOS
UCSC:Q9NXC5 MIOS
Reference Transcript
RefSeq:XM_005249780.3 MIOS
RefSeq:XM_005249782.3 MIOS
RefSeq:NM_019005.3 MIOS
RefSeq:XM_017012361.1 MIOS
RefSeq:XM_005249781.3 MIOS
Other Identifiers
11731629_a_at
17043550
206860_PM_s_at
206860_s_at
209672_3p_s_at
209672_PM_s_at
209672_s_at
211724_PM_x_at
211724_x_at
2989494
2989495
2989496
2989497
2989498
2989499
2989500
2989501
2989502
2989505
2989506
2989507
2989508
2989509
2989510
2989511
2989514
2989515
2989519
2989520
2989523
2989524
2989525
2989526
37917_at
54468
59487_at
8131479
A_23_P59602
A_24_P346388
GE55445
GO:0005515
GO:0005654
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0016020
GO:0030054
GO:0030154
GO:0031503
GO:0031669
GO:0032289
GO:0034198
GO:0043226
GO:0046872
GO:0048709
GO:0061700
GO:0070444
GO:1904262
GO:1904263
HMNXSV003022450
HMNXSV003052313
ILMN_1680644
PH_hs_0024411
TC07000077.hg
g12053282_3p_a_at
g9506672_3p_s_at
Participates
as a component of
GATOR2 [lysosomal membrane] (Homo sapiens)
Inferred To
mios [lysosomal membrane]
(Xenopus tropicalis)
Mios [lysosomal membrane]
(Rattus norvegicus)
Q8VE19 [lysosomal membrane]
(Mus musculus)
MIOS [lysosomal membrane]
(Bos taurus)
MIOS [lysosomal membrane]
(Canis familiaris)
MIOS [lysosomal membrane]
(Gallus gallus)
MIOS [lysosomal membrane]
(Sus scrofa)
Q551B5 [lysosomal membrane]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENST00000405785
,
ENSP00000384088
,
ENSP00000339881
,
ENST00000340080
OpenTargets
ENSG00000164654
HPA
ENSG00000164654-MIOS
PRO
Q9NXC5
Pharos - Targets
Q9NXC5
GlyGen
Q9NXC5
PDB
7UHY
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
SEC13 [cytosol]
(R-HSA-203981)
0.788
8
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.527
2
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