Reactome | SEC31A [ER to Golgi transport vesicle membrane]

SEC31A [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-204010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

Protein transport protein Sec31A, SC31A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC13:SEC31A:SEC23IP [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC31A [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94979 SEC31A

Gene Names

SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334

Chain

chain:1-1220

Reference Genes

BioGPS Gene:22872 SEC31A

COSMIC (genes):SEC31A SEC31A

CTD Gene:22872 SEC31A

dbSNP Gene:22872 SEC31A

ENSEMBL:ENSG00000138674 SEC31A

ENSEMBL_homo_sapiens_GENE:ENSG00000138674.17 SEC31A

HGNC:17052 SEC31A

KEGG Gene (Homo sapiens):22872 SEC31A

Monarch:22872 SEC31A

NCBI Gene:22872 SEC31A

OMIM:610257 SEC31A

UCSC:O94979 SEC31A

Reference Transcript

Other Identifiers

11732334_s_at

11745764_a_at

16977411

200945_PM_s_at

200945_s_at

210616_PM_s_at

210616_s_at

22872

2775755

2775757

2775758

2775759

2775760

2775761

2775764

2775767

2775770

2775771

2775773

2775785

2775786

2775789

2775794

2775795

2775796

2775798

2775801

2775802

2775805

2775807

2775809

2775811

2775812

2775813

2775814

2775815

2775816

2775818

2775819

2775820

2775824

2775825

2775826

2775827

2775828

2775831

2775832

2775833

2775844

2775845

2775848

2775849

35827_at

45494_at

47659_at

8101376

A_23_P170273

A_24_P277349

GE53506

GO:0005198

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0007029

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030120

GO:0030127

GO:0030134

GO:0031410

GO:0043226

GO:0043231

GO:0048306

GO:0048471

GO:0051592

GO:0061024

GO:0070971

GO:0090110

HMNXSV003012075

HMNXSV003048330

ILMN_1691409

ILMN_2399896

PH_hs_0025516

TC04002942.hg

g4240298_3p_a_at

p12351

Participates

as a component of

Other forms of this molecule

SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol]

SEC31A(1-989)-ALK(1058-1620) fusion [cytosol]

SEC31A [endoplasmic reticulum membrane]

SEC31A [cytosol]

Inferred To

SEC31A [ER to Golgi transport vesicle membrane] (Bos taurus)

SEC31A [ER to Golgi transport vesicle membrane] (Canis familiaris)

SEC31A [ER to Golgi transport vesicle membrane] (Gallus gallus)

SEC31A [ER to Golgi transport vesicle membrane] (Plasmodium falciparum)

SEC31A [ER to Golgi transport vesicle membrane] (Sus scrofa)

Sec31a [ER to Golgi transport vesicle membrane] (Mus musculus)

Sec31a [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

sec31 [ER to Golgi transport vesicle membrane] (Dictyostelium discoideum)

sec31 [ER to Golgi transport vesicle membrane] (Schizosaccharomyces pombe)

sec31a [ER to Golgi transport vesicle membrane] (Danio rerio)

sec31a [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

Sec31 [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

SEC31 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

sec-31 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001070675.1, NP_001305048.1, NP_001287674.1, NP_001177978.1, NP_001070676.1, NP_057295.2, NP_001070674.1, NP_001305049.1, NP_001287673.1

OpenTargets

ENSG00000138674

GeneCards

O94979

HPA

ENSG00000138674-SEC31A

Ensembl

ENSG00000138674, ENSP00000400926, ENSP00000347329, ENST00000348405, ENST00000355196, ENSP00000426569, ENSP00000426886, ENSP00000421464, ENST00000508502, ENST00000505984, ENSP00000309070, ENST00000513858, ENSP00000424635, ENSP00000424451, ENST00000509142, ENST00000500777, ENST00000395310, ENSP00000408027, ENSP00000378721, ENST00000311785, ENST00000448323, ENST00000443462, ENSP00000337602

PRO

O94979

Pharos - Targets

O94979

HMDB Protein

HMDBP07990

PDB

7SUL, 3WXA

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75340 PDCD6			0.739	7
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012)	0.734	7
UniProt:Q96KG9 SCYL1			0.708	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	3
UniProt:Q92734 TFG	7	TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG [cytosol] (R-HSA-5688159)	0.527	2
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.508	2

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