Docking of the TAP:EJC Complex with the NPC

Stable Identifier
Reaction [dissociation]
Homo sapiens
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At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.
Literature References
PubMed ID Title Journal Year
10323864 The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

Cullen, BR, Kang, Y

Genes Dev. 1999
11579093 RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex

Guan, T, Paschal, BM, Coyle, J, Guzik, B, Black, BE, Lévesque, L, Hammarskjöld, ML, Rekosh, D

J. Biol. Chem. 2001
9660949 TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus

Izaurralde, E, Saavedra, C, Schmitt, C, Grüter, P, Wilm, M, Tabernero, C, Bachi, A, Felber, BK, von Kobbe, C

Mol. Cell 1998
11256625 Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins

Braun, IC, Izaurralde, E, Doerks, T, Sattler, M, Suyama, M, Bork, P

EMBO Rep. 2000
11756420 Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling

Katahira, J, Straesser, K, Hurt, E, Saiwaki, T, Yoneda, Y

J. Biol. Chem. 2002
10668806 The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

Braun, IC, Carmo-Fonseca, M, Izaurralde, E, Panté, N, Ribbeck, K, Kutay, U, Wilm, M, Bachi, A, von Kobbe, C, Rodrigues, JP, Görlich, D

RNA 2000
10228171 The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

Strässer, K, Podtelejnikov, A, Jung, JU, Katahira, J, Hurt, E, Mann, M

EMBO J. 1999
11739738 Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes

Coburn, GA, Wiegand, HL, Bogerd, HP, Zeng, Y, Kang, Y, Cullen, BR

Mol. Cell. Biol. 2002
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