Docking of the TAP:EJC Complex with the NPC

Stable Identifier
R-HSA-75096
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
ReviewStatus
5/5
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Docking of the TAP:EJC Complex with the NPC
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.
Literature References
PubMed ID Title Journal Year
10323864 The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

Kang, Y, Cullen, BR

Genes Dev. 1999
11579093 RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex

Lévesque, L, Guzik, B, Guan, T, Coyle, J, Black, BE, Rekosh, D, Hammarskjöld, ML, Paschal, BM

J. Biol. Chem. 2001
9660949 TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus

Grüter, P, Tabernero, C, von Kobbe, C, Schmitt, C, Saavedra, C, Bachi, A, Wilm, M, Felber, BK, Izaurralde, E

Mol. Cell 1998
11256625 Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins

Suyama, M, Doerks, T, Braun, IC, Sattler, M, Izaurralde, E, Bork, P

EMBO Rep. 2000
11756420 Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling

Katahira, J, Straesser, K, Saiwaki, T, Yoneda, Y, Hurt, E

J. Biol. Chem. 2002
10668806 The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

Bachi, A, Braun, IC, Rodrigues, JP, Panté, N, Ribbeck, K, von Kobbe, C, Kutay, U, Wilm, M, Görlich, D, Carmo-Fonseca, M, Izaurralde, E

RNA 2000
10228171 The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

Katahira, J, Strässer, K, Podtelejnikov, A, Mann, M, Jung, JU, Hurt, E

EMBO J. 1999
11739738 Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes

Wiegand, HL, Coburn, GA, Zeng, Y, Kang, Y, Bogerd, HP, Cullen, BR

Mol. Cell. Biol. 2002
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
mRNA export from nucleus (0006406)
This event is regulated
Requirements
Created
Hammarskjold, ML  (2003-08-22)
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