Reactome | Ref1 [nucleoplasm]

Ref1 [nucleoplasm]

Stable Identifier

R-DME-8849147

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CHTOP, Q9V3E7

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - RNA Polymerase II Transcription Termination (Drosophila melanogaster)
    - Cleavage of mRNA at the 3'-end (Drosophila melanogaster)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Drosophila melanogaster)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Drosophila melanogaster)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)

Metabolism of RNA (Drosophila melanogaster)

- Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
  - Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Drosophila melanogaster)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Drosophila melanogaster)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Drosophila melanogaster)
        
        TREX (minus DDX39B) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Drosophila melanogaster)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)
  - mRNA 3'-end processing (Drosophila melanogaster)
    - Cleavage of mRNA at the 3'-end (Drosophila melanogaster)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Drosophila melanogaster)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Drosophila melanogaster)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CHTOP [nucleoplasm] (Drosophila melanogaster)
        
        Ref1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V3E7

Gene Names

Ref1

Reference Genes

BioGPS Gene:44029 Ref1

CTD Gene:44029 Ref1

ENSEMBL:FBgn0010774

Flybase:FBgn0010774

KEGG Gene (Drosophila melanogaster):Dmel_CG1101 Ref1

Monarch:44029 Ref1

NCBI Gene:44029 Ref1

UCSC:Q9V3E7 Ref1

Reference Transcript

RefSeq:NM_143711.3 Ref1

Other Identifiers

154296_at

1634966_a_at

1640178_at

44029

GO:0000346

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0006397

GO:0008150

GO:0031965

GO:0032991

GO:0034641

GO:0043226

GO:0071011

GO:0071013

Participant Of

hasMember

Homologues of CHTOP [nucleoplasm]

Other forms of this molecule

Ref1 [nucleoplasm]

Ref1 [cytosol]

Inferred From

CHTOP [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_651968.1

Flybase

FBgn0010774

PRO

Q9V3E7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9VAF3 Q9VAF3			0.488	2
UniProt:Q9VEF0	6	Odj [nucleoplasm] (R-DME-1027348-3) Odj [nucleoplasm] (R-DME-2586599-3) Odj [nucleoplasm] (R-DME-2454144-3) Odj [nucleoplasm] (R-DME-2248876-3) Odj [nucleoplasm] (R-DME-2248870-3) Odj [nucleoplasm] (R-DME-2248867-3)	0.488	2
UniProt:Q24568 NETB			0.462	2