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THOC2 [nucleoplasm]
Stable Identifier
R-HSA-8849134
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
THO complex subunit 2, THOC2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NI27 THOC2
Gene Names
THOC2, CXorf3
Chain
chain:1-1593
Reference Genes
BioGPS Gene:57187 THOC2
COSMIC (genes):THOC2 THOC2
CTD Gene:57187 THOC2
dbSNP Gene:57187 THOC2
ENSEMBL:ENSG00000125676 THOC2
HGNC:19073 THOC2
KEGG:hsa:57187 THOC2
Monarch:57187 THOC2
NCBI Gene:57187 THOC2
OMIM:300395 THOC2
UCSC:Q8NI27 THOC2
Reference Transcript
RefSeq:NM_001081550.1 THOC2
Other Identifiers
11734766_a_at
11734767_at
11734768_s_at
11734769_a_at
11744605_a_at
11759635_x_at
11759636_x_at
11764244_s_at
17113866
212994_PM_at
212994_at
222122_PM_s_at
222122_s_at
226626_PM_at
226626_at
226628_PM_at
226628_at
32124_at
32125_at
4020442
4020443
4020445
4020446
4020447
4020448
4020449
4020450
4020453
4020454
4020455
4020456
4020457
4020458
4020460
4020463
4020464
4020465
4020466
4020467
4020468
4020469
4020470
4020471
4020472
4020473
4020474
4020475
4020476
4020477
4020478
4020479
4020480
4020481
4020482
4020483
4020484
4020485
4020486
4020487
4020488
4020489
4020490
4020493
4020494
4020496
4020497
4020498
4020499
4020500
4020501
4020502
4020503
4020504
4020505
4020506
4020507
4020508
4020511
4020515
4020516
4020517
4020518
4020524
4020526
4020527
4020528
4020529
4020530
4020532
4020535
4020538
4020539
43040_at
48246_r_at
57187
8174893
A_23_P11051
A_24_P177353
A_33_P3235690
GE55903
GE56611
GO:0000346
GO:0000347
GO:0000445
GO:0000781
GO:0000902
GO:0001824
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0006397
GO:0006406
GO:0006913
GO:0008380
GO:0010468
GO:0010793
GO:0010977
GO:0016071
GO:0016607
GO:0016973
GO:0017145
GO:0030154
GO:0043226
GO:0048666
GO:0048699
GO:0048856
GO:0051028
HMNXSV003032539
Hs.16411.0.S1_3p_at
Hs.16411.1.S1_3p_a_at
Hs.81376.0.S1_3p_at
Hs.81376.0.S2_3p_at
ILMN_1696883
ILMN_2390821
PH_hs_0035474
TC0X001342.hg
Participates
as a component of
THO complex [nucleoplasm] (Homo sapiens)
Inferred To
Thoc2 [nucleoplasm]
(Mus musculus)
Thoc2 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of THOC2 [nucleoplasm]
(Danio rerio)
thoc-2 [nucleoplasm]
(Caenorhabditis elegans)
THOC2 [nucleoplasm]
(Bos taurus)
THOC2 [nucleoplasm]
(Canis familiaris)
THOC2 [nucleoplasm]
(Gallus gallus)
THOC2 [nucleoplasm]
(Sus scrofa)
thoc2 [nucleoplasm]
(Dictyostelium discoideum)
tho2 [nucleoplasm]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000355725
,
ENST00000618150
,
ENSG00000125676
,
ENST00000245838
,
ENSP00000480478
,
ENSP00000245838
,
ENSP00000347959
OpenTargets
ENSG00000125676
GeneCards
THOC2
HPA
ENSG00000125676-THOC2
PRO
Q8NI27
Pharos - Targets
Q8NI27
GlyGen
Q8NI27
Orphanet
THOC2
PDB
7APK
,
7ZNK
,
7ZNL
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13838 DDX39B
2
DDX39B [nucleoplasm]
(R-HSA-8849139)
DDX39B [cytosol]
(R-HSA-9715154)
0.643
3
UniProt:Q13769 THOC5
3
THOC5 [nucleoplasm]
(R-HSA-8849111)
THOC5 [cytosol]
(R-HSA-9682751)
p-Y-THOC5 [cytosol]
(R-HSA-9682738)
0.643
4
UniProt:Q86V81 ALYREF
2
ALYREF [cytosol]
(R-HSA-158482)
ALYREF [nucleoplasm]
(R-HSA-156649)
0.643
4
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