Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NHEJ1 [nucleoplasm]
Stable Identifier
R-HSA-5687247
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
XLF, Non-homologous end-joining factor 1, Protein cernunnos, XRCC4-like factor
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
NHEJ1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H9Q4 NHEJ1
Gene Names
NHEJ1, XLF
Chain
chain:1-299
Reference Genes
BioGPS Gene:79840 NHEJ1
COSMIC (genes):NHEJ1 NHEJ1
CTD Gene:79840 NHEJ1
dbSNP Gene:79840 NHEJ1
ENSEMBL:ENSG00000187736 NHEJ1
HGNC:25737 NHEJ1
KEGG:hsa:79840 NHEJ1
Monarch:79840 NHEJ1
NCBI Gene:79840 NHEJ1
OMIM:611290 NHEJ1
UCSC:Q9H9Q4 NHEJ1
Reference Transcript
RefSeq:NM_024782.2 NHEJ1
Participates
as a component of
NHEJ1 [nucleoplasm] (Homo sapiens)
Inferred To
Nhej1 [nucleoplasm]
(Mus musculus)
Nhej1 [nucleoplasm]
(Rattus norvegicus)
NHEJ1 [nucleoplasm]
(Bos taurus)
NHEJ1 [nucleoplasm]
(Canis familiaris)
NHEJ1 [nucleoplasm]
(Dictyostelium discoideum)
NHEJ1 [nucleoplasm]
(Gallus gallus)
NHEJ1 [nucleoplasm]
(Sus scrofa)
nhej1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000187736
ENSEMBL
ENSG00000187736
,
ENSP00000513606
,
ENST00000409720
,
ENSP00000513605
,
ENST00000356853
,
ENST00000698174
,
ENSP00000349313
,
ENST00000457600
,
ENSP00000407201
,
ENST00000698202
,
ENSP00000387290
,
ENSP00000513594
,
ENST00000698203
HPA
ENSG00000187736-NHEJ1
GeneCards
NHEJ1
PRO
Q9H9Q4
Pharos - Targets
Q9H9Q4
Orphanet
NHEJ1
GlyGen
Q9H9Q4
PDB
3Q4F
,
8BOT
,
3SR2
,
2R9A
,
3W03
,
7LSY
,
6ERG
,
6ERH
,
3RWR
,
7NFE
,
7NFC
,
8EZA
,
8EZB
,
8BHV
,
8BHY
,
7LT3
,
2QM4
,
7ZYG
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13426 XRCC4
2
XRCC4 [nucleoplasm]
(R-HSA-75911)
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
0.868
11
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text