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RNF135 [cytosol]
Stable Identifier
R-HSA-936042
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RING finger protein 135, RN135_HUMAN, REUL, Riplet
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
DDX58 is K63 polyubiquitinated (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
DDX58 is K63 polyubiquitinated (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
MAVS interacts with RIPK1 and FADD (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Processing of caspases (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of IKK complex (Homo sapiens)
dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Interaction of PCBP2 with MAVS (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of IRF3,IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of TRAF3 to MAVS (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1 or IKBKE forms homodimers (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Phosphorylation of TBK1/IKBKE (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of TANK to TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TBK1, IKBKE form homodimers (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Activation of IKK by MEKK1 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Interaction of MEKK1 with TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
RNF135 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IUD6 RNF135
Gene Names
RNF135, L13
Chain
chain:1-432
Reference Genes
BioGPS Gene:84282 RNF135
COSMIC (genes):RNF135 RNF135
CTD Gene:84282 RNF135
dbSNP Gene:84282 RNF135
ENSEMBL:ENSG00000181481.14 RNF135
HGNC:21158 RNF135
KEGG Gene (Homo sapiens):84282 RNF135
Monarch:84282 RNF135
NCBI Gene:84282 RNF135
OMIM:611358 RNF135
UCSC:Q8IUD6 RNF135
Reference Transcript
RefSeq:NM_001184992.1 RNF135
RefSeq:NM_032322.3 RNF135
RefSeq:NM_197939.1 RNF135
Other Identifiers
0002850008
0002850292
11735429_x_at
11736287_a_at
16832896
223591_PM_at
223591_at
223592_PM_s_at
223592_s_at
2344801
3716995
3716996
3716997
3716998
3717001
3717002
3717003
3717004
3717006
3717007
3717008
3717009
3717010
44536_at
73743_at
8006229
84282
86371_at
A_14_P120660
A_23_P252283
A_24_P39759
GE83378
GO:0000209
GO:0002376
GO:0004842
GO:0005515
GO:0005622
GO:0005737
GO:0005829
GO:0010494
GO:0010994
GO:0016567
GO:0016740
GO:0023052
GO:0032728
GO:0032991
GO:0036211
GO:0039529
GO:0039552
GO:0042802
GO:0043021
GO:0043226
GO:0045087
GO:0045088
GO:0046872
GO:0051260
GO:0061630
GO:0065003
GO:0070534
GO:0098542
GO:0140096
GO:0140374
GO:1990904
HMNXSV003006661
ILMN_1700660
ILMN_1721625
ILMN_1738883
ILMN_2407529
PH_hs_0028839
TC17000358.hg
g13477234_3p_at
g13477234_3p_s_at
Participates
as a member of
RNF135,TRIM25,TRIM4 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001171921.1
,
NP_922921.1
,
NP_115698.3
OpenTargets
ENSG00000181481
GeneCards
Q8IUD6
HPA
ENSG00000181481-RNF135
Ensembl
ENST00000328381
,
ENSP00000440470
,
ENSP00000328340
,
ENSP00000323693
,
ENSG00000181481
,
ENST00000535306
,
ENST00000324689
PRO
Q8IUD6
Pharos - Targets
Q8IUD6
Orphanet
16944
PDB
7JL3
,
7JL1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
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