Reactome | RNF135 [cytosol]

RNF135

Stable Identifier

R-HSA-936042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RING finger protein 135, RN135_HUMAN, REUL, Riplet

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - DDX58 is K63 polyubiquitinated (Homo sapiens)
      - 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - MAVS interacts with RIPK1 and FADD (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Interaction of PCBP2 with MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF3-dependent IRF activation pathway (Homo sapiens)
      - Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IRF3,IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TRAF3 to MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF6 mediated IRF7 activation (Homo sapiens)
      - Phosphorylation and release of IRF7 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of IRF7 to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TANK to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - TRAF6 mediated NF-kB activation (Homo sapiens)
      - Activation of IKK by MEKK1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - Interaction of MEKK1 with TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
    - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ovarian tumor domain proteases (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        RNF135,TRIM25 [cytosol] (Homo sapiens)
        
        RNF135 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IUD6 RNF135

Gene Names

RNF135, L13

Chain

chain:1-432

Reference Genes

BioGPS Gene:84282 RNF135

COSMIC (genes):RNF135 RNF135

CTD Gene:84282 RNF135

dbSNP Gene:84282 RNF135

ENSEMBL:ENSG00000181481 RNF135

HGNC:21158 RNF135

KEGG Gene (Homo sapiens):hsa:84282 RNF135

Monarch:84282 RNF135

NCBI Gene:84282 RNF135

OMIM:611358 RNF135

UCSC:Q8IUD6 RNF135

Reference Transcript

Other Identifiers

0002850008

0002850292

11735429_x_at

11736287_a_at

16832896

21576

223591_at

223592_s_at

2344801

3716994

3716995

3716996

3716997

3716998

3717001

3717002

3717003

3717004

3717006

3717007

3717008

3717009

3717010

44536_at

52404

73743_at

8006229

84282

86371_at

A_14_P120660

A_23_P252283

A_24_P39759

AAH05084

AAI26421

AAI26423

AAT06743

AB470605

AC138207

AJ496729

AK122646

AK312979

AY598332

BAG35816

BAG53638

BAG84604

BC005084

BC082262

BC126420

BC126422

CAD43140

CCDS11262

CCDS11263

CCDS54104

CH471147

EAW80286

ENSG00000181481

ENSP00000323693

ENSP00000328340

ENSP00000440470

ENST00000324689

ENST00000328381

ENST00000535306

EntrezGene:84282

g13477234_3p_at

g13477234_3p_s_at

GE83378

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006464

GO:0006950

GO:0008150

GO:0016567

GO:0016579

GO:0016740

GO:0032480

GO:0032728

GO:0042802

GO:0043021

GO:0043167

GO:0045087

GO:0045088

GO:0046872

HGNC:21158

HPA021576

HPA052404

ILMN_1700660

ILMN_1721625

ILMN_1738883

ILMN_2407529

IPR001841

IPR001870

IPR003877

IPR003879

IPR006574

IPR013083

IPR013320

IPR017907

MIM:611358

MIM:614192

NM_001184992

NM_032322

NM_197939

NP_001171921

NP_115698

NP_922921

PF00622

PF15227

PH_hs_0028839

PR01407

RNF135

RNF135-201

RNF135-202

RNF135-205

SM00184

SM00449

SM00589

TC17000358.hg

uc002hfz.4

uc002hga.4

uc010csm.4

UPI0000072456

UPI00001AF795

UPI0000D4C294

XM_005258043

XM_017025223

XP_005258100

XP_016880712

Participant Of

hasMember

RNF135,TRIM25 [cytosol]

Cross References

RefSeq

NP_001171921.1, NP_922921.1, NP_115698.3

GeneCards

Q8IUD6

PRO

Q8IUD6

BRENDA (Homo sapiens)

2.3.2.27

Orphanet

16944

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.696	5