PIAS1,2-1 SUMOylates XRCC4 with SUMO1

Stable Identifier
R-HSA-4568848
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIAS1,2-1 SUMOylates XRCC4 with SUMO1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1,2-1 SUMOylate XRCC4 at lysine-210 with SUMO1 (Yurchenko et al. 2006). SUMOylation causes localization of XRCC4 to the nucleus. (An unSUMOylatable mutant of XRCC4 is localized to the cytosol.)

Literature References
PubMed ID Title Journal Year
16478998 SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair

Xue, Z, Sadofsky, MJ, Yurchenko, V

Mol. Cell. Biol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of PIAS1,2-1 [nucleoplasm]

Physical Entity
PIAS1,2-1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Danio rerio)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Dictyostelium discoideum)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Mus musculus)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-09-14)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-19)
Cite Us!