Reactome | LIG4 [nucleoplasm]

LIG4 [nucleoplasm]

Stable Identifier

R-HSA-53791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA ligase IV , Polydeoxyribonucleotide synthase (ATP)

Locations in the PathwayBrowser

for Species:

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External Reference Information

External Reference

UniProt:P49917 LIG4

Gene Names

LIG4

Chain

chain:1-911

Reference Genes

BioGPS Gene:3981 LIG4

COSMIC (genes):LIG4 LIG4

CTD Gene:3981 LIG4

dbSNP Gene:3981 LIG4

ENSEMBL:ENSG00000174405 LIG4

HGNC:6601 LIG4

KEGG:hsa:3981 LIG4

Monarch:3981 LIG4

NCBI Gene:3981 LIG4

OMIM:601837 LIG4

UCSC:P49917 LIG4

Reference Transcript

Other Identifiers

11724945_x_at

16780896

206235_PM_at

206235_at

227766_3p_at

227766_PM_at

227766_at

3525000

3525001

3525002

3525003

3525004

3525005

3525007

3525008

3525009

3525010

3525011

3525012

3525013

3525014

3525015

3525016

3525017

3525018

3981

7972737

91213_at

963_at

A_23_P25581

A_24_P415839

A_24_P415845

GE60085

GO:0000012

GO:0000287

GO:0000781

GO:0000793

GO:0001701

GO:0002328

GO:0002376

GO:0003677

GO:0003824

GO:0003909

GO:0003910

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005958

GO:0006266

GO:0006281

GO:0006297

GO:0006302

GO:0006303

GO:0006310

GO:0007417

GO:0008283

GO:0010165

GO:0010212

GO:0010332

GO:0012501

GO:0016874

GO:0022008

GO:0030154

GO:0032807

GO:0033077

GO:0033151

GO:0033152

GO:0033153

GO:0035019

GO:0043226

GO:0043231

GO:0043524

GO:0045190

GO:0046872

GO:0048144

GO:0048146

GO:0048856

GO:0050769

GO:0051102

GO:0051103

GO:0051276

GO:0051301

GO:0051402

GO:0070419

GO:0071285

GO:0071479

GO:0071897

GO:0072089

GO:0075713

GO:0097680

GO:0140097

GO:1904155

GO:2001252

HMNXSV003043996

Hs.22039.1.A1_3p_at

Hs.22039.1.A1_3p_x_at

ILMN_1680714

ILMN_1693758

ILMN_2373073

PH_hs_0010004

TC13000867.hg

X83441_at

g4504996_3p_at

Participates

as a component of

XRCC4:LIG4 [nucleoplasm] (Homo sapiens)

Inferred To

lig4 [nucleoplasm] (Xenopus tropicalis)

DNAlig4 [nucleoplasm] (Drosophila melanogaster)

LIG4 [nucleoplasm] (Bos taurus)

LIG4 [nucleoplasm] (Canis familiaris)

LIG4 [nucleoplasm] (Dictyostelium discoideum)

LIG4 [nucleoplasm] (Gallus gallus)

LIG4 [nucleoplasm] (Mus musculus)

LIG4 [nucleoplasm] (Sus scrofa)

Lig4 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011519394.1, XP_006720014.1, XP_011519393.1, XP_006720015.1, NP_001091738.1, XP_005254115.1, XP_005254114.1, NP_001317524.1, NP_002303.2, XP_016876058.1, XP_016876059.1, XP_005254113.1, NP_996820.1, XP_016876060.1, XP_016876062.1

OpenTargets

ENSG00000174405

ENSEMBL

ENST00000611712, ENST00000688455, ENST00000686095, ENST00000687822, ENST00000693040, ENSP00000509122, ENSP00000509502, ENSP00000508512, ENSP00000509304, ENSP00000510014, ENSP00000509942, ENST00000687164, ENST00000688396, ENSP00000509906, ENSP00000509344, ENSP00000484288, ENST00000688595, ENSP00000509564, ENSP00000509685, ENST00000686913, ENSP00000385955, ENST00000686204, ENST00000442234, ENST00000692222, ENST00000688529, ENSP00000509226, ENST00000405925, ENSP00000509299, ENSP00000510567, ENSP00000402030, ENST00000686926, ENST00000685338

HPA

ENSG00000174405-LIG4

PRO

P49917

Pharos - Targets

P49917

Orphanet

LIG4

HMDB Protein

HMDBP00588

PDB

6BKG, 3W5O, 2E2W, 8BHV, 7LSY, 8BHY, 4HTO, 7NFE, 7LT3, 6BKF, 7NFC, 8BOT, 7D9Y, 3W1B, 8EZA, 8BH3, 3W1G, 7D9K, 8EZB, 3VNN, 3II6, 1IK9, 4HTP

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.964	22
UniProt:Q96SD1 DCLRE1C	3	DCLRE1C [nucleoplasm] (R-HSA-5686712) p-S645-DCLRE1C [nucleoplasm] (R-HSA-5686708) p-S516,S645-DCLRE1C [nucleoplasm] (R-HSA-5687176)	0.788	16
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cilium] (R-HSA-5632507) CSNK1A1 [cytosol] (R-HSA-195263)	0.527	2