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DCLRE1C [nucleoplasm]
Stable Identifier
R-HSA-5686712
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein artemis, ARTEMIS, ASCID, SCIDA, SNM1C
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
Activated ATM phosphorylates DCLRE1C (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
DCLRE1C [nucleoplasm] (Homo sapiens)
TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
DCLRE1C [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
DCLRE1C [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96SD1 DCLRE1C
Gene Names
DCLRE1C, ARTEMIS, ASCID, SCIDA, SNM1C
Chain
chain:1-692
Reference Genes
BioGPS Gene:64421 DCLRE1C
COSMIC (genes):DCLRE1C DCLRE1C
CTD Gene:64421 DCLRE1C
dbSNP Gene:64421 DCLRE1C
ENSEMBL:ENSG00000152457 DCLRE1C
ENSEMBL_homo_sapiens_GENE:ENSG00000152457.19 DCLRE1C
HGNC:17642 DCLRE1C
KEGG Gene (Homo sapiens):64421 DCLRE1C
Monarch:64421 DCLRE1C
NCBI Gene:64421 DCLRE1C
OMIM:605988 DCLRE1C
UCSC:Q96SD1 DCLRE1C
Reference Transcript
RefSeq:NM_001033855.2 DCLRE1C
RefSeq:NM_001033857.2 DCLRE1C
RefSeq:XM_011519619.1 DCLRE1C
RefSeq:NM_001033858.2 DCLRE1C
RefSeq:XM_017016557.1 DCLRE1C
RefSeq:NM_001289076.1 DCLRE1C
RefSeq:NM_001289077.1 DCLRE1C
RefSeq:NM_001289078.1 DCLRE1C
RefSeq:XM_017016558.1 DCLRE1C
RefSeq:NM_001289079.1 DCLRE1C
RefSeq:NM_022487.3 DCLRE1C
RefSeq:XM_006717491.3 DCLRE1C
RefSeq:XM_011519616.1 DCLRE1C
RefSeq:XM_011519617.1 DCLRE1C
Other Identifiers
11729488_x_at
11735416_x_at
11762018_at
16712001
219678_PM_x_at
219678_x_at
222233_PM_s_at
222233_s_at
235478_PM_at
235478_at
239376_PM_at
239376_at
242927_PM_at
242927_at
3278976
3278978
3278979
3278980
3278983
3278984
3278985
3278986
3278987
3278988
3278989
3278990
3278991
3278992
3278993
3278994
3278995
3278997
3279000
3279002
3279003
3279004
3279005
3279006
3279007
3279009
3279014
3279016
3279024
3279025
3279026
3279027
3279028
3279029
3279057
3279060
3279066
44030_at
50951_at
55844_at
59248_at
64421
7932186
91960_at
A_23_P86632
A_23_P86635
A_24_P186401
A_33_P3386219
GE845362
GE84998
GO:0000014
GO:0000723
GO:0002250
GO:0002376
GO:0003677
GO:0003684
GO:0003824
GO:0004518
GO:0004519
GO:0004527
GO:0005515
GO:0005634
GO:0005654
GO:0005794
GO:0006281
GO:0006302
GO:0006303
GO:0006310
GO:0006974
GO:0008409
GO:0010212
GO:0016787
GO:0030154
GO:0030183
GO:0032200
GO:0033151
GO:0035312
GO:0036297
GO:0043226
GO:0048856
GO:0051276
GO:0070419
GO:0140097
HMNXSV003019927
HMNXSV003056611
Hs.14665.0.A1_3p_at
Hs.28891.1.S1_3p_a_at
Hs.295448.0.A1_3p_at
Hs.311638.0.A1_3p_at
ILMN_1754211
ILMN_2321931
PH_hs_0016550
PH_hs_0024142
TC10002480.hg
TC10002932.hg
p28325
Participates
as a component of
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Homo sapiens)
as an input of
TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)
Other forms of this molecule
p-S516,S645-DCLRE1C [nucleoplasm]
p-S645-DCLRE1C [nucleoplasm]
Inferred To
Ghost homologue of DCLRE1C [nucleoplasm]
(Schizosaccharomyces pombe)
DCLRE1C [nucleoplasm]
(Bos taurus)
DCLRE1C [nucleoplasm]
(Canis familiaris)
DCLRE1C [nucleoplasm]
(Gallus gallus)
DCLRE1C [nucleoplasm]
(Sus scrofa)
Dclre1c [nucleoplasm]
(Mus musculus)
Dclre1c [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001276006.1
,
NP_001029027.1
,
XP_006717554.1
,
NP_001029029.1
,
NP_001276007.1
,
XP_016872046.1
,
XP_011517919.1
,
NP_071932.2
,
NP_001029030.1
,
XP_011517921.1
,
NP_001276008.1
,
XP_011517918.1
,
XP_016872047.1
,
NP_001276005.1
OpenTargets
ENSG00000152457
GeneCards
Q96SD1
HPA
ENSG00000152457-DCLRE1C
Ensembl
ENST00000378278
,
ENST00000378289
,
ENSG00000152457
,
ENST00000697075
,
ENSP00000513090
,
ENSP00000367538
,
ENSP00000367527
PRO
Q96SD1
Pharos - Targets
Q96SD1
Orphanet
15852
PDB
3W1B
,
7SGL
,
7AFU
,
6TT5
,
7AFS
,
7AGI
,
7TYR
,
7AF1
,
7ABS
,
6WO0
,
3W1G
,
4HTP
,
7APV
,
6WNL
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49917 LIG4
1
LIG4 [nucleoplasm]
(R-HSA-53791)
0.788
16
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.702
5
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.462
3
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