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Ub-ERCC6 [nucleoplasm]
Stable Identifier
R-HSA-6781853
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ub-CSB
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub-ERCC6 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub-ERCC6 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub-ERCC6 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub-ERCC6 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Ub-ERCC6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03468 ERCC6
Gene Names
ERCC6, CSB
Chain
chain:1-1493
Reference Genes
BioGPS Gene:2074 ERCC6
COSMIC (genes):ERCC6 ERCC6
CTD Gene:2074 ERCC6
dbSNP Gene:2074 ERCC6
ENSEMBL:ENSG00000225830 ERCC6
ENSEMBL_homo_sapiens_GENE:ENSG00000225830.16 ERCC6
KEGG Gene (Homo sapiens):2074 ERCC6
Monarch:2074 ERCC6
NCBI Gene:2074 ERCC6
OMIM:609413 ERCC6
UCSC:Q03468 ERCC6
Reference Transcript
RefSeq:NM_001346440.1 ERCC6
RefSeq:NM_000124.3 ERCC6
Other Identifiers
11740066_a_at
11740067_a_at
207347_PM_at
207347_at
2074
2080_s_at
230108_PM_at
230108_at
3288690
3288692
3288694
3288696
3288698
3288699
3288701
3288703
3288705
3288706
3288708
3288709
3288710
3288711
3288713
3288714
3288717
3288718
3288719
3288720
3288723
3288724
3288725
3288726
3288727
3288729
3288731
3288733
3288737
3288740
3288745
3288757
3288758
3288759
3288760
3288761
3288762
3288763
3288766
3288769
3288770
3288771
3288773
35043_at
49088_at
57645_at
7933509
82563_at
A_23_P1292
A_32_P230192
GE532073
GE678978
GE80893
GO:0000012
GO:0000077
GO:0000166
GO:0000303
GO:0003677
GO:0003682
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006281
GO:0006283
GO:0006284
GO:0006290
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006362
GO:0006366
GO:0006974
GO:0006979
GO:0007254
GO:0007399
GO:0008023
GO:0008094
GO:0008630
GO:0009411
GO:0009636
GO:0010165
GO:0010224
GO:0010332
GO:0012501
GO:0016787
GO:0016887
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030296
GO:0031175
GO:0032784
GO:0032786
GO:0034243
GO:0035066
GO:0035264
GO:0036211
GO:0042262
GO:0043226
GO:0045494
GO:0045739
GO:0045943
GO:0045944
GO:0045945
GO:0048856
GO:0060261
GO:0090734
GO:0097680
GO:0098772
GO:0110016
GO:0140097
GO:0140657
GO:0140658
GO:1905168
GO:2001033
HMNXSV003027371
Hs.98361.0.A1_3p_at
ILMN_1786882
PH_hs_0031107
TC10001276.hg
g4557564_3p_at
Participates
as a component of
Ub:ERCC6 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ERCC6 [nucleoplasm]
Inferred To
Ub-ERCC6 [nucleoplasm]
(Caenorhabditis elegans)
Ub-ERCC6 [nucleoplasm]
(Gallus gallus)
Ub-ERCC6 [nucleoplasm]
(Mus musculus)
Ub-ERCC6 [nucleoplasm]
(Saccharomyces cerevisiae)
Ub-ERCC6 [nucleoplasm]
(Schizosaccharomyces pombe)
Ercc6 [nucleoplasm]
(Rattus norvegicus)
ERCC6 [nucleoplasm]
(Bos taurus)
ERCC6 [nucleoplasm]
(Canis familiaris)
ercc6 [nucleoplasm]
(Dictyostelium discoideum)
ercc6 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of Ub-ERCC6 [nucleoplasm]
(Danio rerio)
Ghost homologue of Ub-ERCC6 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of Ub-ERCC6 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of Ub-ERCC6 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_000115.1
,
NP_001333369.1
OpenTargets
ENSG00000225830
GeneCards
Q03468
Ensembl
ENST00000355832
,
ENSP00000348089
,
ENSG00000225830
PRO
Q03468
Pharos - Targets
Q03468
Orphanet
15991
PDB
7OOB
,
8B3F
,
7OPC
,
7OO3
,
8B3D
,
4CVO
,
7OPD
,
7OOP
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00519 ABL1
6
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.655
8
UniProt:Q13216-1 ERCC8
0.527
2
UniProt:P24928 POLR2A
7
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
POLR2A [nucleoplasm]
(R-HSA-63502)
0.499
2
UniProt:Q9HCS7 XAB2
1
XAB2 [nucleoplasm]
(R-HSA-67411)
0.499
2
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