Reactome | MED26 [nucleoplasm]

MED26 [nucleoplasm]

Stable Identifier

R-HSA-556783

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mediator of RNA polymerase II transcription subunit 26, MED26_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        NS1 (1C) binds to Mediator complex (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED26 [nucleoplasm] (Homo sapiens)
        
        Mediator:NS1 [nucleoplasm] (Homo sapiens)
        
        Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
        
        MED26 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95402 MED26

Gene Names

MED26, ARC70, CRSP7

Chain

chain:1-600

Reference Genes

BioGPS Gene:9441 MED26

COSMIC (genes):MED26 MED26

CTD Gene:9441 MED26

dbSNP Gene:9441 MED26

ENSEMBL:ENSG00000105085 MED26

ENSEMBL_homo_sapiens_GENE:ENSG00000105085.11 MED26

HGNC:2376 MED26

KEGG Gene (Homo sapiens):9441 MED26

Monarch:9441 MED26

NCBI Gene:9441 MED26

OMIM:605043 MED26

UCSC:O95402 MED26

Reference Transcript

RefSeq:NM_004831.3 MED26

Other Identifiers

11750320_a_at

11754467_s_at

16870060

227538_PM_at

227538_at

231724_PM_at

231724_at

3854029

3854033

3854034

3854035

3854036

3854038

3854058

3854059

3854060

3854063

3854065

50104_at

8035187

9441

A_23_P164737

A_23_P317854

GE61858

GE80371

GO:0003712

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0006367

GO:0010628

GO:0016592

GO:0032968

GO:0043226

GO:0051123

GO:0060261

GO:0065003

GO:0070847

GO:0140110

HMNXSV003018916

Hs.241381.0.S1_3p_at

Hs.241381.0.S1_3p_x_at

Hs.4867.3.A1_3p_at

ILMN_1718171

PH_hs_0024006

TC19002689.hg

Participates

as a component of

as an input of

Formation of ARC coactivator complex (Homo sapiens)

Inferred To

MED26 [nucleoplasm] (Bos taurus)

MED26 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004822.2

OpenTargets

ENSG00000105085

HPA

ENSG00000105085-MED26

GeneCards

O95402

Ensembl

ENSP00000484490, ENST00000611692, ENSG00000105085, ENSP00000263390, ENST00000263390

PRO

O95402

Pharos - Targets

O95402

PDB

7ENJ, 6ZV3, 7EMF, 5ODD, 8GXS, 7ENA, 8GXQ, 7ENC

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.901	12
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.877	12
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.873	15
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.864	10
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.788	9
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.788	13
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.788	6
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.725	6
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.725	6
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.725	8
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.725	8
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.725	7
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.725	6
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.708	6
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.643	5
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.643	4
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.643	5
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.643	6
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.643	5
UniProt:Q9P086 MED11	1	MED11 [nucleoplasm] (R-HSA-556808)	0.643	4
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.643	4
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.643	5
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.643	8
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.527	4
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.527	4
UniProt:Q96RN5 MED15	1	MED15 [nucleoplasm] (R-HSA-556827)	0.527	3
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502)	0.527	8
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.527	4
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.527	3
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	3
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	5
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.527	3
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	3
UniProt:P52434 POLR2H	2	POLR2H [nucleoplasm] (R-HSA-63523) POLR2H [cytosol] (R-HSA-1964450)	0.527	3
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.527	3
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.527	3
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.527	3
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.527	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.527	4
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.527	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q71F56 MED13L	1	MED13L [nucleoplasm] (R-HSA-556797)	0.527	4
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.527	3
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2
UniProt:P0CAP2 GRL1A			0.527	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.499	5

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