Reactome | RPAP2 [nucleoplasm]

RPAP2 [nucleoplasm]

Stable Identifier

R-HSA-6810227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 ecNumber3.1.3.16/ecNumber, RPAP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IXW5 RPAP2

Gene Names

RPAP2, C1orf82

Chain

initiator methionine:, chain:2-612

Reference Genes

BioGPS Gene:79871 RPAP2

COSMIC (genes):RPAP2 RPAP2

CTD Gene:79871 RPAP2

dbSNP Gene:79871 RPAP2

ENSEMBL:ENSG00000122484 RPAP2

ENSEMBL_homo_sapiens_GENE:ENSG00000122484.9 RPAP2

HGNC:25791 RPAP2

KEGG Gene (Homo sapiens):79871 RPAP2

Monarch:79871 RPAP2

NCBI Gene:79871 RPAP2

OMIM:611476 RPAP2

UCSC:Q8IXW5 RPAP2

Reference Transcript

RefSeq:NM_024813.2 RPAP2

Other Identifiers

11728778_at

11750757_a_at

16667140

219504_PM_s_at

219504_s_at

222893_PM_s_at

222893_s_at

2346740

2346741

2346742

2346743

2346744

2346745

2346746

2346748

2346749

2346750

2346751

2346755

2346756

2346757

2346760

2346761

2346762

2346763

2346764

2346765

2346766

2346767

2346768

2346769

2346770

2346771

2346772

2346773

2346774

2346775

2346811

2346813

2346815

2346816

2346818

2346819

2346820

3298899

51616_at

62734_r_at

7902992

79871

A_14_P111864

A_23_P23542

A_33_P3243897

GE86251

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0008420

GO:0009301

GO:0016073

GO:0016787

GO:0017018

GO:0023052

GO:0036499

GO:0043175

GO:0043226

GO:0046872

GO:0097550

GO:0140096

HMNXSV003015500

HMNXSV003046648

HMNXSV003049847

Hs.169728.0.S1_3p_a_at

ILMN_1657754

ILMN_1844993

PH_hs_0010117

TC01000853.hg

TC01004529.hg

g13376201_3p_a_at

p1057

Participates

as an output of

Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)

as a component of

as an input of

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)

Inferred To

Ghost homologue of RPAP2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of RPAP2 [nucleoplasm] (Schizosaccharomyces pombe)

RPAP2 [nucleoplasm] (Bos taurus)

RPAP2 [nucleoplasm] (Caenorhabditis elegans)

RPAP2 [nucleoplasm] (Canis familiaris)

RPAP2 [nucleoplasm] (Danio rerio)

RPAP2 [nucleoplasm] (Dictyostelium discoideum)

RPAP2 [nucleoplasm] (Gallus gallus)

RPAP2 [nucleoplasm] (Mus musculus)

RPAP2 [nucleoplasm] (Rattus norvegicus)

RPAP2 [nucleoplasm] (Saccharomyces cerevisiae)

RPAP2 [nucleoplasm] (Sus scrofa)

rpap2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_079089.2

OpenTargets

ENSG00000122484

IntEnz

3.1.3.16

GeneCards

Q8IXW5

HPA

ENSG00000122484-RPAP2

Ensembl

ENSP00000476948, ENST00000610020, ENSG00000122484

PRO

Q8IXW5

Pharos - Targets

Q8IXW5

HMDB Protein

HMDBP11917

PDB

7F4G, 7B7U

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCN4 GPN1			0.8	9
UniProt:Q9NWS0 PIHD1			0.8	8
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.757	6
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.643	5
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.643	4
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.643	5
UniProt:Q9UHW5 GPN3			0.643	4
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502)	0.643	4
UniProt:Q96P16-1 RPRD1A			0.591	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.527	3
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.527	2
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.527	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	2
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.527	4
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
UniProt:P0CAP1 MYZAP			0.527	2
UniProt:P0CAP2 GRL1A			0.527	2
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.527	2
UniProt:P52434 POLR2H	2	POLR2H [nucleoplasm] (R-HSA-63523) POLR2H [cytosol] (R-HSA-1964450)	0.527	2
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	2