Reactome | GIP(22-153) [endoplasmic reticulum lumen]

GIP(22-153) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-400512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

ProGIP, pro-Glucose-dependent Insulinotropic Polypeptide, pro-Gastric Inhibitory Peptide

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09681 GIP

Gene Names

GIP

Chain

signal peptide:1-21, propeptide:22-50, peptide:52-93, propeptide:95-153

Reference Genes

BioGPS Gene:2695 GIP

COSMIC (genes):GIP GIP

CTD Gene:2695 GIP

dbSNP Gene:2695 GIP

ENSEMBL:ENSG00000159224 GIP

HGNC:4270 GIP

KEGG:hsa:2695 GIP

Monarch:2695 GIP

NCBI Gene:2695 GIP

OMIM:137240 GIP

UCSC:P09681 GIP

Reference Transcript

RefSeq:NM_004123.2 GIP

Other Identifiers

11734238_at

16846363

207899_PM_at

207899_at

2695

3761662

3761663

3761665

3761666

3761667

3761669

3761670

611_at

8016523

A_23_P141459

GE57854

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005788

GO:0007165

GO:0007189

GO:0007565

GO:0007613

GO:0008344

GO:0009410

GO:0009743

GO:0009749

GO:0010269

GO:0010447

GO:0010828

GO:0014070

GO:0019233

GO:0022414

GO:0031018

GO:0031667

GO:0031767

GO:0031769

GO:0032024

GO:0033993

GO:0034774

GO:0035640

GO:0038192

GO:0042304

GO:0042594

GO:0043025

GO:0043200

GO:0043434

GO:0043950

GO:0048018

GO:0048678

GO:0048856

GO:0050796

GO:0050806

GO:0050877

GO:0055123

GO:0060291

GO:0070328

GO:0098772

HMNXSV003053141

ILMN_1673805

M18185_at

PH_hs_0000196

TC17001657.hg

g4758435_3p_at

Participates

as an output of

Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)

as an input of

ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)

Other forms of this molecule

GIP(22-153) [secretory granule lumen]

GIP(52-93) [secretory granule lumen]

GIP(54-93) [extracellular region]

GIP(1-153) [endoplasmic reticulum lumen]

GIP(52-93) [extracellular region]

Inferred To

GIP(22-153) [endoplasmic reticulum lumen] (Gallus gallus)

gip [endoplasmic reticulum lumen] (Danio rerio)

gip [endoplasmic reticulum lumen] (Xenopus tropicalis)

GIP [endoplasmic reticulum lumen] (Bos taurus)

GIP [endoplasmic reticulum lumen] (Canis familiaris)

GIP [endoplasmic reticulum lumen] (Sus scrofa)

Gip [endoplasmic reticulum lumen] (Mus musculus)

Gip [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_004114.1

ENSEMBL

ENST00000357424, ENSP00000350005

OpenTargets

ENSG00000159224

HPA

ENSG00000159224-GIP

ZINC - Substances

GIP_HUMAN

ZINC target

P09681

PRO

P09681

Pharos - Targets

P09681

ZINC - Predictions - Purchasable

GIP_HUMAN

PDB

1T5Q, 2QKH, 2OBU, 7DTY, 2B4N, 7RA3, 2L70, 2L71

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.718	6
UniProt:P48546 GIPR	1	GIPR [plasma membrane] (R-HSA-420132)	0.618	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	2
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2