Reactome | GIP(52-93) [extracellular region]

GIP(52-93) [extracellular region]

Stable Identifier

R-HSA-400540

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Glucose-dependent Insulinotropic Polypeptide, Gastric Inhibitory Peptide, GIP

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External Reference Information

External Reference

UniProt:P09681 GIP

Gene Names

GIP

Chain

signal peptide:1-21, propeptide:22-50, peptide:52-93, propeptide:95-153

Reference Genes

BioGPS Gene:2695 GIP

COSMIC (genes):GIP GIP

CTD Gene:2695 GIP

dbSNP Gene:2695 GIP

ENSEMBL:ENSG00000159224 GIP

HGNC:4270 GIP

KEGG:hsa:2695 GIP

Monarch:2695 GIP

NCBI Gene:2695 GIP

OMIM:137240 GIP

UCSC:P09681 GIP

Reference Transcript

RefSeq:NM_004123.2 GIP

Other Identifiers

11734238_at

16846363

207899_PM_at

207899_at

2695

3761662

3761663

3761665

3761666

3761667

3761669

3761670

611_at

8016523

A_23_P141459

GE57854

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005788

GO:0007165

GO:0007189

GO:0007565

GO:0007613

GO:0008344

GO:0009410

GO:0009743

GO:0009749

GO:0010269

GO:0010447

GO:0010828

GO:0014070

GO:0019233

GO:0022414

GO:0031018

GO:0031667

GO:0031767

GO:0031769

GO:0032024

GO:0033993

GO:0034774

GO:0035640

GO:0038192

GO:0042304

GO:0042594

GO:0043025

GO:0043200

GO:0043434

GO:0043950

GO:0048018

GO:0048678

GO:0048856

GO:0050796

GO:0050806

GO:0050877

GO:0055123

GO:0060291

GO:0070328

GO:0098772

HMNXSV003053141

ILMN_1673805

M18185_at

PH_hs_0000196

TC17001657.hg

g4758435_3p_at

Participates

as an input of

as an output of

Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)

as a component of

GIPR:GIP(52-93) [plasma membrane] (Homo sapiens)

Other forms of this molecule

GIP(22-153) [endoplasmic reticulum lumen]

GIP(22-153) [secretory granule lumen]

GIP(52-93) [secretory granule lumen]

GIP(54-93) [extracellular region]

GIP(1-153) [endoplasmic reticulum lumen]

Inferred To

Gip [extracellular region] (Mus musculus)

Gip [extracellular region] (Rattus norvegicus)

GIP [extracellular region] (Bos taurus)

GIP [extracellular region] (Canis familiaris)

GIP [extracellular region] (Sus scrofa)

GIP(52-93) [extracellular region] (Gallus gallus)

gip [extracellular region] (Danio rerio)

gip [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_004114.1

ENSEMBL

ENST00000357424, ENSG00000159224, ENSP00000350005

OpenTargets

ENSG00000159224

GeneCards

GIP

HPA

ENSG00000159224-GIP

ZINC - Substances

GIP_HUMAN

ZINC target

P09681

PRO

P09681

Pharos - Targets

P09681

ZINC - Predictions - Purchasable

GIP_HUMAN

PDB

7RA3, 2B4N, 7DTY, 2QKH, 2OBU, 1T5Q, 2L71, 2L70

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.718	6
UniProt:P48546 GIPR	1	GIPR [plasma membrane] (R-HSA-420132)	0.618	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	2
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.527	2