Reactome | p-Y-IL6ST [plasma membrane]

p-Y-IL6ST [plasma membrane]

Stable Identifier

R-HSA-8950439

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
14764690	WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 Pflanz, S, Hibbert, L, Mattson, J, Rosales, R, Vaisberg, E, Bazan, JF, Phillips, JH, McClanahan, TK, de Waal Malefyt, R, Kastelein, RA	J Immunol	2004

External Reference Information

External Reference

UniProt:P40189 IL6ST

Gene Names

IL6ST

Chain

signal peptide:1-22, chain:23-918

Reference Genes

BioGPS Gene:3572 IL6ST

COSMIC - genes:IL6ST IL6ST

CTD Gene:3572 IL6ST

dbSNP Gene:3572 IL6ST

ENSEMBL:ENSG00000134352 IL6ST

HGNC:6021 IL6ST

KEGG:hsa:3572 IL6ST

Monarch:3572 IL6ST

NCBI Gene:3572 IL6ST

OMIM:600694 IL6ST

UCSC:P40189 IL6ST

Reference Transcript

Participates

as a component of

p-Y-IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

IL6ST [plasma membrane]

Inferred To

phospho-IL6ST [plasma membrane] (Bos taurus)

phospho-IL6ST [plasma membrane] (Canis familiaris)

phospho-IL6ST [plasma membrane] (Sus scrofa)

phospho-Il6st [plasma membrane] (Mus musculus)

phospho-Il6st [plasma membrane] (Rattus norvegicus)

phospho-il6st [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_786943.1, NP_001177910.1, NP_002175.2

Guide to Pharmacology - Targets

2317

OpenTargets

ENSG00000134352

ENSEMBL

ENSP00000370694, ENST00000502326, ENSG00000134352, ENST00000522633, ENST00000698645, ENST00000381294, ENSP00000370698, ENST00000381298, ENSP00000435399, ENSP00000513858, ENSP00000462158

HPA

ENSG00000134352-IL6ST

GeneCards

IL6ST

PRO

P40189

Pharos - Targets

P40189

GlyGen

P40189

PDB

3L5J, 3L5I, 3L5H, 1P9M, 1BQU, 1PVH, 8D85, 8D74, 8DPT, 8D82, 8DPU, 8D7R, 1BJ8, 8V29, 1I1R, 8UPA, 8V2A, 8DPS, 8D6A, 7U7N

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.836	7
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.779	12
UniProt:P13725 OSM	1	OSM [extracellular region] (R-HSA-5696440)	0.759	5
UniProt:P15018 LIF	1	LIF [extracellular region] (R-HSA-5696436)	0.743	4
UniProt:Q96EQ0 SGTB			0.666	4
UniProt:P42227 Stat3	13	phospho-Stat3 [nucleoplasm] (R-MMU-1112554) phospho-Stat3 [cytosol] (R-MMU-914048) Stat3 [cytosol] (R-MMU-539044) Stat3 [cytosol] (R-MMU-914084) p-Y705-Stat3 [cytosol] (R-MMU-914034) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-8983130) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [nucleoplasm] (R-MMU-9701429) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [nucleoplasm] (R-MMU-9701435) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.656	4
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.601	7
UniProt:Q6UWB1 IL27RA	4	IL27RA [plasma membrane] (R-HSA-448478) p-Y611-IL27RA [plasma membrane] (R-HSA-8950330) sIL27RA [extracellular region] (R-HSA-8950454) sIL27RA [cytoplasm] (R-HSA-8950653)	0.592	3
UniProt:P43364 MAGAB			0.556	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:Q9NZI2-2 Q9NZI22-1			0.556	3
UniProt:Q2HRC7 VIL6			0.544	2
UniProt:O14967 CLGN			0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.527	2
UniProt:O00526 UPK2			0.527	2
UniProt:Q9UBD9 CLCF1	1	CLCF1 [extracellular region] (R-HSA-5693175)	0.488	2
UniProt:P42702 LIFR	1	LIFR [plasma membrane] (R-HSA-5693181)	0.488	2

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