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FGF21 [extracellular region]
Stable Identifier
R-HSA-189909
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fibroblast growth factor-21, FGFL_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Cellular hexose transport (Homo sapiens)
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
FGF21 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NSA1 FGF21
Gene Names
FGF21, UNQ3115/PRO10196
Chain
signal peptide:1-28, chain:29-209
Reference Genes
BioGPS Gene:26291 FGF21
COSMIC (genes):FGF21 FGF21
CTD Gene:26291 FGF21
dbSNP Gene:26291 FGF21
ENSEMBL:ENSG00000105550 FGF21
HGNC:3678 FGF21
KEGG:hsa:26291 FGF21
Monarch:26291 FGF21
NCBI Gene:26291 FGF21
OMIM:609436 FGF21
UCSC:Q9NSA1 FGF21
Reference Transcript
RefSeq:NM_019113.3 FGF21
Other Identifiers
11735831_at
16863871
221433_PM_at
221433_at
26291
3837985
3837986
3837987
3837988
3837989
3837990
3837991
3837992
8030105
A_14_P135843
A_23_P101564
GE82474
GO:0001934
GO:0005104
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0007165
GO:0007267
GO:0008083
GO:0008284
GO:0008543
GO:0009887
GO:0010628
GO:0010898
GO:0010988
GO:0012501
GO:0014823
GO:0023052
GO:0030154
GO:0030334
GO:0030968
GO:0031667
GO:0043410
GO:0046326
GO:0048018
GO:0070374
GO:0071333
GO:0071377
GO:0071404
GO:0071466
GO:0072577
GO:0090080
GO:0098772
GO:0120162
GO:1904640
GO:1905599
GO:2000352
HMNXSV003037210
ILMN_1772789
ILMN_2056569
PH_hs_0014584
TC19000710.hg
g9506596_3p_at
This entity regulates
Positively
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
(Homo sapiens)
Other forms of this molecule
FGF21 [cytosol]
Inferred To
FGF21 [extracellular region]
(Bos taurus)
FGF21 [extracellular region]
(Sus scrofa)
FGF8C [extracellular region]
(Canis familiaris)
bnl [extracellular region]
(Drosophila melanogaster)
Fgf21 [extracellular region]
(Mus musculus)
Fgf21 [extracellular region]
(Rattus norvegicus)
egl-17 [extracellular region]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000593756
,
ENSP00000471477
,
ENSG00000105550
,
ENST00000222157
,
ENSP00000222157
OpenTargets
ENSG00000105550
GeneCards
FGF21
HPA
ENSG00000105550-FGF21
PRO
Q9NSA1
Pharos - Targets
Q9NSA1
PDB
5VAQ
,
6M6F
,
6M6E
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.61
4
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:P46379-2 BAG6
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:O14645 IDLC
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
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