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GIP(1-153) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-400470
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
PreproGIP, prepro Glucose-dependent insulinotropic polypeptide alternativeName: prepro-Gastric inhibitory polypeptide shortName:preproGIP, GIP_HUMAN, GIP
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)
GIP(1-153) [endoplasmic reticulum lumen] (Homo sapiens)
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
GIP(1-153) [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09681 GIP
Gene Names
GIP
Chain
signal peptide:1-21, propeptide:22-50, peptide:52-93, propeptide:95-153
Reference Genes
BioGPS Gene:2695 GIP
COSMIC (genes):GIP GIP
CTD Gene:2695 GIP
dbSNP Gene:2695 GIP
ENSEMBL:ENSG00000159224 GIP
HGNC:4270 GIP
KEGG Gene (Homo sapiens):2695 GIP
Monarch:2695 GIP
NCBI Gene:2695 GIP
OMIM:137240 GIP
UCSC:P09681 GIP
Reference Transcript
RefSeq:NM_004123.2 GIP
Other Identifiers
0000460204
11734238_at
16846363
207899_at
2695
3761662
3761663
3761665
3761666
3761667
3761669
3761670
611_at
8016523
A_23_P141459
GE57854
GO:0000003
GO:0002376
GO:0002862
GO:0003674
GO:0005102
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0006629
GO:0006810
GO:0006950
GO:0007165
GO:0007186
GO:0007267
GO:0007565
GO:0007613
GO:0008150
GO:0008344
GO:0009058
GO:0009743
GO:0009749
GO:0010269
GO:0010447
GO:0010828
GO:0014070
GO:0015031
GO:0019233
GO:0031018
GO:0031410
GO:0031667
GO:0031769
GO:0032024
GO:0033993
GO:0034774
GO:0035640
GO:0042304
GO:0042493
GO:0042592
GO:0042594
GO:0043025
GO:0043200
GO:0043226
GO:0043434
GO:0043950
GO:0044281
GO:0048678
GO:0048856
GO:0050796
GO:0050806
GO:0050877
GO:0055085
GO:0055123
GO:0060291
GO:0070094
GO:0070328
HMNXSV003053141
ILMN_1673805
M18185_at
PH_hs_0000196
TC17001657.hg
g4758435_3p_at
Participates
as an input of
Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)
as an output of
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
Other forms of this molecule
GIP(22-153) [endoplasmic reticulum lumen]
GIP(22-153) [secretory granule lumen]
GIP(52-93) [secretory granule lumen]
GIP(54-93) [extracellular region]
GIP(52-93) [extracellular region]
Cross References
RefSeq
NP_004114.1
OpenTargets
ENSG00000159224
ZINC - Substances
GIP_HUMAN
GeneCards
P09681
HPA
ENSG00000159224-GIP
Ensembl
ENSG00000159224
,
ENST00000357424
,
ENSP00000350005
ZINC target
P09681
PRO
P09681
Pharos - Targets
P09681
ZINC - Predictions - Purchasable
GIP_HUMAN
PDB
2B4N
,
2L70
,
1T5Q
,
7DTY
,
2QKH
,
2OBU
,
2L71
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.718
6
UniProt:P48546 GIPR
1
GIPR [plasma membrane]
(R-HSA-420132)
0.618
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
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