Reactome | Jup [plasma membrane]

Jup [plasma membrane]

Stable Identifier

R-RNO-437260

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

JUP, Q6P0K8

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Rattus norvegicus)

- Cell junction organization (Rattus norvegicus)
  - Cell-cell junction organization (Rattus norvegicus)
    - Adherens junctions interactions (Rattus norvegicus)
      - Regulation of Homotypic Cell-Cell Adhesion (Rattus norvegicus)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Rattus norvegicus)
        
        Regulation of CDH11 Expression and Function (Rattus norvegicus)
        
        Regulation of CDH11 function (Rattus norvegicus)
        
        CDH11 associates with catenins (Rattus norvegicus)
        
        CDH11:CTNND1:CTNNB1/JUP [plasma membrane] (Rattus norvegicus)
        
        CDH11:CTNND1:JUP [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
        
        CTNNB1/JUP [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)

Developmental Biology (Rattus norvegicus)

- Keratinization (Rattus norvegicus)
  - Formation of the cornified envelope (Rattus norvegicus)
    - CASP14 cleaves filaggrin (Rattus norvegicus)
      - Late cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Cornified envelope:CDSN [plasma membrane] (Rattus norvegicus)
        
        Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Early cornified envelope [plasma membrane] (Rattus norvegicus)
        
        FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
      - Mature cornified envelope [plasma membrane] (Rattus norvegicus)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Rattus norvegicus)
        
        No FGN-Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        No FGN-late cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
    - CDSN binds the cornified envelope (Rattus norvegicus)
      - Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Early cornified envelope [plasma membrane] (Rattus norvegicus)
        
        FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
      - Cornified envelope:CDSN [plasma membrane] (Rattus norvegicus)
        
        Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Early cornified envelope [plasma membrane] (Rattus norvegicus)
        
        FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Rattus norvegicus)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
      - FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
    - Lamellar bodies bind the early cornified envelope (Rattus norvegicus)
      - Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Early cornified envelope [plasma membrane] (Rattus norvegicus)
        
        FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
      - Early cornified envelope [plasma membrane] (Rattus norvegicus)
        
        FLG-Keratin filament network [plasma membrane] (Rattus norvegicus)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
    - PERP binds desmosomes (Rattus norvegicus)
      - Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
      - Desmosome:PERP [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
    - Plasma membrane resorption (Rattus norvegicus)
      - Mature cornified envelope [plasma membrane] (Rattus norvegicus)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Rattus norvegicus)
        
        No FGN-Cornified envelope [plasma membrane] (Rattus norvegicus)
        
        No FGN-late cornified envelope [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Rattus norvegicus)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
        
        Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
  - Keratin filaments bind cell-cell adhesion complexes (Rattus norvegicus)
    - Desmosome [plasma membrane] (Rattus norvegicus)
      - Jup [plasma membrane] (Rattus norvegicus)
    - Keratin tonofilament:Desmosome [plasma membrane] (Rattus norvegicus)
      - Desmosome [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by VEGF (Rattus norvegicus)
    - VEGFA-VEGFR2 Pathway (Rattus norvegicus)
      - VEGFR2 mediated vascular permeability (Rattus norvegicus)
        
        PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)
        
        VE-cadherin-Catenin complex [plasma membrane] (Rattus norvegicus)
        
        Beta-catenin/gamma catenin [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)
        
        p-S665-VE-cadherin-Catenin complex [plasma membrane] (Rattus norvegicus)
        
        Beta-catenin/gamma catenin [plasma membrane] (Rattus norvegicus)
        
        Jup [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6P0K8

Gene Names

Jup

Reference Genes

BioGPS Gene:81679 Jup

ENSEMBL:ENSRNOG00000015380

ENSEMBL:ENSRNOG00000015380.7 Jup

ENSEMBL:ENSRNOG00055033360

ENSEMBL:ENSRNOG00060025951

ENSEMBL:ENSRNOG00065032933

KEGG Gene (Rattus norvegicus):81679 Jup

Monarch:81679 Jup

NCBI Gene:81679 Jup

UCSC:Q6P0K8 Jup

Reference Transcript

Other Identifiers

10747330

1387061_at

17661334

5673331

5717014

5790943

5818770

5876357

5888813

5892341

5977195

6004789

6393186

6431682

6441083

6453198

6464241

6499142

6633286

6658536

81679

A_44_P334788

GE20979

GO:0005515

GO:0007155

GO:0045296

ILMN_1359114

PH_rn_0014689

U58858_at

Participates

as a component of

as a member of

Other forms of this molecule

Jup [cytosol]

Jup [cornified envelope]

Jup [specific granule lumen]

Jup [extracellular region]

Jup [ficolin-1-rich granule lumen]

Inferred From

JUP [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006247491.1, XP_017453037.1, NP_112309.2, XP_006247492.1

Ensembl

ENSRNOP00000043950, ENSRNOG00000015380, ENSRNOT00000040845

PRO

Q6P0K8

RGD

620412

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