Reactome | hmp-2 [plasma membrane]

hmp-2 [plasma membrane]

Stable Identifier

R-CEL-437260

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

plasma membrane

Synonyms

JUP, O44326

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Keratinization (Caenorhabditis elegans)
  - Formation of the cornified envelope (Caenorhabditis elegans)
    - PERP binds desmosomes (Caenorhabditis elegans)
      - Desmosome [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of JUP [plasma membrane] (Caenorhabditis elegans)
        
        hmp-2 [plasma membrane] (Caenorhabditis elegans)
      - Desmosome:PERP [plasma membrane] (Caenorhabditis elegans)
        
        Desmosome [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of JUP [plasma membrane] (Caenorhabditis elegans)
        
        hmp-2 [plasma membrane] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by VEGF (Caenorhabditis elegans)
    - VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
      - VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
        
        PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)
        
        VE-cadherin-Catenin complex [plasma membrane] (Caenorhabditis elegans)
        
        Beta-catenin/gamma catenin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of JUP [plasma membrane] (Caenorhabditis elegans)
        
        hmp-2 [plasma membrane] (Caenorhabditis elegans)
        
        p-S665-VE-cadherin-Catenin complex [plasma membrane] (Caenorhabditis elegans)
        
        Beta-catenin/gamma catenin [plasma membrane] (Caenorhabditis elegans)
        
        Homologues of JUP [plasma membrane] (Caenorhabditis elegans)
        
        hmp-2 [plasma membrane] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O44326

Gene Names

hmp-2

Reference Genes

BioGPS Gene:173338 hmp-2

ENSEMBL:WBGene00001979

Monarch:173338 hmp-2

NCBI Gene:173338 hmp-2

UCSC:O44326 hmp-2

Wormbase:WBGene00001979

Reference Transcript

RefSeq:NM_001265497.1 hmp-2

Other Identifiers

173338

18457881

193907_at

A_12_P105979

CE19974

CE_WBGene00001979_A

CE_WBGene00001979_B

CE_WBGene00001979_C

CGZ0027911

GO:0000132

GO:0003713

GO:0005515

GO:0005634

GO:0005737

GO:0005912

GO:0006355

GO:0007010

GO:0007155

GO:0009792

GO:0010172

GO:0016342

GO:0016477

GO:0016922

GO:0019901

GO:0019903

GO:0019904

GO:0030866

GO:0032880

GO:0042074

GO:0043226

GO:0044331

GO:0045294

GO:0045296

GO:0045944

GO:0048856

GO:0048870

GO:0051782

GO:0060070

GO:0060090

GO:0070161

GO:0070986

GO:0098609

GO:0098772

GO:0140110

GO:0140678

K05C4.6

K05C4.6_1085-1144_0.879_28_B

K05C4.6_1284-1343_0.903_17_A

K05C4.6_1753-1812_0.955_2_C

K05C4_6P00599

K05C4_6P00786

K05C4_6P01752

WBGene00001979

cea2.c.04836

Participates

as a member of

Homologues of JUP [plasma membrane] (Caenorhabditis elegans)

Other forms of this molecule

hmp-2 [cytosol]

hmp-2 [ficolin-1-rich granule lumen]

hmp-2 [extracellular region]

hmp-2 [specific granule lumen]

phospho-hmp-2 [nucleoplasm]

phospho-hmp-2 [cytosol]

hmp-2 [plasma membrane]

hmp-2 [cytosol]

hmp-2 [nucleoplasm]

Inferred From

JUP [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001252426.1

ENSEMBL

K05C4.6a.1

PRO

O44326

PDB

4R0Z, 5XA5, 4R11, 4R10

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q967F4 HMR1			0.785	5
UniProt:Q09506	1	txbp-3 [cytosol] (R-CEL-5666217)	0.553	2