Reactome | Jup [plasma membrane]

Jup [plasma membrane]

Stable Identifier

R-SSC-437260-2

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

JUP, Q8WNW3

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-cell junction organization (Sus scrofa)
    - Adherens junctions interactions (Sus scrofa)
      - Activation of STAT3 by cadherin engagement (Sus scrofa)
        
        Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Sus scrofa)
        
        Engaged CDH1,(CDH11) [plasma membrane] (Sus scrofa)
        
        Homotypic CDH11 trans dimer [plasma membrane] (Sus scrofa)
        
        CDH11:CTNDD1:CTNNB1/JUP:CTNNA1 [plasma membrane] (Sus scrofa)
        
        CDH11:CTNND1:JUP:CTNNA1 [plasma membrane] (Sus scrofa)
        
        CDH11:CTNND1:JUP [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)
        
        Beta-catenin/gamma catenin [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
        
        Cadherin:Catenin complex [plasma membrane] (Sus scrofa)
        
        Beta-catenin/gamma catenin [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Sus scrofa)
        
        Regulation of CDH11 Expression and Function (Sus scrofa)
        
        Regulation of CDH11 function (Sus scrofa)
        
        CDH11 associates with catenins (Sus scrofa)
        
        CDH11:CTNND1:CTNNB1/JUP [plasma membrane] (Sus scrofa)
        
        CDH11:CTNND1:JUP [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
        
        CTNNB1/JUP [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)

Developmental Biology (Sus scrofa)

- Keratinization (Sus scrofa)
  - Formation of the cornified envelope (Sus scrofa)
    - CASP14 cleaves filaggrin (Sus scrofa)
      - Late cornified envelope [plasma membrane] (Sus scrofa)
        
        Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - CDSN binds the cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - Lamellar bodies bind the early cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - PERP binds desmosomes (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
      - Desmosome:PERP [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - Plasma membrane resorption (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
  - Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)
    - Desmosome [plasma membrane] (Sus scrofa)
      - Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
    - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - VEGFR2 mediated vascular permeability (Sus scrofa)
        
        PAK1-3 phosphorylates VE-cadherin (Sus scrofa)
        
        VE-cadherin-Catenin complex [plasma membrane] (Sus scrofa)
        
        Beta-catenin/gamma catenin [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)
        
        p-S665-VE-cadherin-Catenin complex [plasma membrane] (Sus scrofa)
        
        Beta-catenin/gamma catenin [plasma membrane] (Sus scrofa)
        
        Homologues of JUP [plasma membrane] (Sus scrofa)
        
        Jup [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q8WNW3

Gene Names

Jup

Reference Genes

BioGPS Gene:397592 Jup

ENSEMBL:ENSSSCG00015043128

KEGG:ssc:397592 Jup

Monarch:397592 Jup

NCBI Gene:397592 Jup

UCSC:Q8WNW3 Jup

Reference Transcript

RefSeq:NM_214323.1 Jup

Participates

as a member of

Homologues of JUP [plasma membrane] (Sus scrofa)

Other forms of this molecule

Jup [cornified envelope]

Jup [specific granule lumen]

Jup [extracellular region]

Jup [ficolin-1-rich granule lumen]

phospho-Jup [cytosol]

Jup [cytosol]

Inferred From

JUP [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_999488.1

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