Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
P2RY12 [plasma membrane]
Stable Identifier
R-HSA-391959
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2Y purinoceptor 12, P2Y12_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Gi activation by P2Y purinoceptor 12 (Homo sapiens)
ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12 binds ADP (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:P2RY12 antagonists [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
P2Y receptors (Homo sapiens)
P2RY12 binds ADP (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:P2RY12 antagonists [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12 binds P2RY12 antagonists (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
P2RY12:P2RY12 antagonists [plasma membrane] (Homo sapiens)
P2RY12 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H244 P2RY12
Gene Names
P2RY12, HORK3
Chain
chain:1-342
Reference Genes
BioGPS Gene:64805 P2RY12
COSMIC (genes):P2RY12 P2RY12
CTD Gene:64805 P2RY12
dbSNP Gene:64805 P2RY12
ENSEMBL:ENSG00000169313 P2RY12
ENSEMBL:ENSG00000169313.10 P2RY12
HGNC:18124 P2RY12
KEGG Gene (Homo sapiens):64805 P2RY12
Monarch:64805 P2RY12
NCBI Gene:64805 P2RY12
OMIM:600515 P2RY12
UCSC:Q9H244 P2RY12
Reference Transcript
RefSeq:XM_017007069.1 P2RY12
RefSeq:NM_022788.4 P2RY12
RefSeq:NM_176876.2 P2RY12
Other Identifiers
11751382_a_at
16960577
224102_PM_at
224102_at
235885_PM_at
235885_at
2701080
2701082
2701083
2701084
2701085
2701086
2701087
2701088
2701089
2701090
2701091
2701098
64805
8091530
81716_at
A_23_P143902
GE79283
GO:0001609
GO:0001621
GO:0001973
GO:0002376
GO:0004930
GO:0005085
GO:0005886
GO:0006629
GO:0006811
GO:0006930
GO:0007155
GO:0007165
GO:0007186
GO:0007188
GO:0007193
GO:0007200
GO:0007202
GO:0007596
GO:0007599
GO:0009986
GO:0016020
GO:0019722
GO:0021808
GO:0023052
GO:0030030
GO:0030032
GO:0030154
GO:0030168
GO:0031253
GO:0033626
GO:0033630
GO:0035585
GO:0035589
GO:0042060
GO:0043270
GO:0043552
GO:0044298
GO:0045028
GO:0048678
GO:0048856
GO:0048870
GO:0050920
GO:0050921
GO:0051649
GO:0051897
GO:0060089
GO:0065003
GO:0070527
GO:0071318
GO:0071407
GO:0098772
GO:0150063
GO:1900029
GO:1904139
GO:1904141
HMNXSV003019987
Hs.123222.0.A1_3p_at
ILMN_2320164
PH_hs_0026015
PH_hs_0036163
TC03001907.hg
g12656597_3p_at
Participates
as an input of
P2RY12 binds P2RY12 antagonists (Homo sapiens)
P2RY12 binds ADP (Homo sapiens)
as an output of
Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
as a component of
P2RY12:P2RY12 antagonists [plasma membrane] (Homo sapiens)
P2RY12:ADP [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of P2RY12 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of P2RY12 [plasma membrane]
(Gallus gallus)
p2ry12 [plasma membrane]
(Xenopus tropicalis)
P2RY12 [plasma membrane]
(Bos taurus)
P2RY12 [plasma membrane]
(Canis familiaris)
P2RY12 [plasma membrane]
(Danio rerio)
P2RY12 [plasma membrane]
(Mus musculus)
P2RY12 [plasma membrane]
(Rattus norvegicus)
P2RY12 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016862558.1
,
NP_795345.1
,
NP_073625.1
ZINC - World Drugs
P2Y12_HUMAN
Guide to Pharmacology - Targets
328
OpenTargets
ENSG00000169313
ZINC - FDA approved
P2Y12_HUMAN
ZINC - Substances
P2Y12_HUMAN
ZINC target
Q9H244
ZINC - Biogenic
P2Y12_HUMAN
PRO
Q9H244
PDB
4PY0
,
4PXZ
,
4NTJ
,
7PP1
ZINC - Investigational
P2Y12_HUMAN
ZINC - Metabolites
P2Y12_HUMAN
HPA
ENSG00000169313-P2RY12
GeneCards
Q9H244
Ensembl
ENSG00000169313
,
ENSP00000307259
,
ENST00000302632
Pharos - Targets
Q9H244
ZINC - Predictions - Purchasable
P2Y12_HUMAN
Orphanet
16601
HMDB Protein
HMDBP02244
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text