Reactome | P2RY12 [plasma membrane]

P2RY12 [plasma membrane]

Stable Identifier

R-HSA-391959

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P2Y purinoceptor 12, P2Y12_HUMAN

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External Reference Information

External Reference

UniProt:Q9H244 P2RY12

Gene Names

P2RY12, HORK3

Chain

chain:1-342

Reference Genes

BioGPS Gene:64805 P2RY12

COSMIC (genes):P2RY12 P2RY12

CTD Gene:64805 P2RY12

dbSNP Gene:64805 P2RY12

ENSEMBL:ENSG00000169313 P2RY12

HGNC:18124 P2RY12

KEGG:hsa:64805 P2RY12

Monarch:64805 P2RY12

NCBI Gene:64805 P2RY12

OMIM:600515 P2RY12

UCSC:Q9H244 P2RY12

Reference Transcript

Other Identifiers

11751382_a_at

16960577

224102_PM_at

224102_at

235885_PM_at

235885_at

2701080

2701082

2701083

2701084

2701085

2701086

2701087

2701088

2701089

2701090

2701091

2701092

2701093

2701098

64805

8091530

81716_at

A_23_P143902

GE79283

GO:0001609

GO:0001621

GO:0001973

GO:0004930

GO:0005085

GO:0005886

GO:0006811

GO:0006930

GO:0007155

GO:0007186

GO:0007188

GO:0007193

GO:0007200

GO:0007596

GO:0007599

GO:0009986

GO:0016020

GO:0019722

GO:0021801

GO:0030030

GO:0030032

GO:0030168

GO:0031253

GO:0033626

GO:0033630

GO:0035589

GO:0043270

GO:0044298

GO:0045028

GO:0048678

GO:0048856

GO:0048870

GO:0050920

GO:0050921

GO:0051649

GO:0051897

GO:0060089

GO:0070527

GO:0071318

GO:0071407

GO:0098772

GO:0150063

GO:1900029

GO:1904139

GO:1904141

HMNXSV003019987

Hs.123222.0.A1_3p_at

ILMN_2320164

PH_hs_0026015

PH_hs_0036163

TC03001907.hg

g12656597_3p_at

Participates

as an input of

as an output of

Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)

as a component of

Inferred To

Ghost homologue of P2RY12 [plasma membrane] (Caenorhabditis elegans)

Ghost homologue of P2RY12 [plasma membrane] (Drosophila melanogaster)

Ghost homologue of P2RY12 [plasma membrane] (Gallus gallus)

p2ry12 [plasma membrane] (Danio rerio)

p2ry12 [plasma membrane] (Xenopus tropicalis)

P2RY12 [plasma membrane] (Bos taurus)

P2RY12 [plasma membrane] (Canis familiaris)

P2RY12 [plasma membrane] (Mus musculus)

P2RY12 [plasma membrane] (Rattus norvegicus)

P2RY12 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_073625.1, XP_016862558.1, NP_795345.1

ZINC - World Drugs

P2Y12_HUMAN

Guide to Pharmacology - Targets

328

OpenTargets

ENSG00000169313

ENSEMBL

ENSP00000307259, ENST00000302632

ZINC - FDA approved

P2Y12_HUMAN

ZINC - Substances

P2Y12_HUMAN

ZINC - Biogenic

P2Y12_HUMAN

ZINC target

Q9H244

PRO

Q9H244

GlyGen

Q9H244

PDB

4PXZ, 4NTJ, 4PY0, 7XXI, 7PP1

ZINC - Investigational

P2Y12_HUMAN

ZINC - Metabolites

P2Y12_HUMAN

HPA

ENSG00000169313-P2RY12

Pharos - Targets

Q9H244

Orphanet

P2RY12

ZINC - Predictions - Purchasable

P2Y12_HUMAN

HMDB Protein

HMDBP02244

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.527	2
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.527	2
UniProt:Q6ZMG9 CERS6	1	CERS6 [endoplasmic reticulum membrane] (R-HSA-428145)	0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:P53794 SLC5A3	1	SLC5A3 [plasma membrane] (R-HSA-429592)	0.527	2
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q5U3C3 TM164			0.527	2
UniProt:Q9UFG5 CS025			0.527	2
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	2
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.527	2
UniProt:Q8N5B7 CERS5	1	CERS5 [endoplasmic reticulum membrane] (R-HSA-428168)	0.527	2
UniProt:Q9NWZ8 GEMIN8	2	GEMIN8 [nucleoplasm] (R-HSA-8932892) GEMIN8 [cytosol] (R-HSA-8932878)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:Q6GMV3 PTRD1			0.527	2
UniProt:Q9HD45 TM9S3			0.527	2
UniProt:Q9H4A6 GOLP3			0.527	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2
UniProt:P53004 BLVRA	1	BLVRA [cytosol] (R-HSA-189390)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	2
UniProt:Q8NHS3 MFSD8			0.527	2
UniProt:Q96K19 RN170			0.527	2
UniProt:Q14571 ITPR2	2	ITPR2 [platelet dense tubular network membrane] (R-HSA-418281) ITPR2 [endoplasmic reticulum membrane] (R-HSA-3006467)	0.527	2
UniProt:Q8TBA6 GOLGA5	2	GOLGA5 [transport vesicle] (R-HSA-8847517) GOLGA5 [Golgi membrane] (R-HSA-8847514)	0.527	2