Reactome | MRS2 [mitochondrial inner membrane]

MRS2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5216072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Magnesium transporter MRS2 homolog, mitochondrial, MRS2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9HD23 MRS2

Gene Names

MRS2, HPT, MRS2L

Chain

transit peptide:1-49, chain:50-443

Reference Genes

BioGPS Gene:57380 MRS2

COSMIC (genes):MRS2 MRS2

CTD Gene:57380 MRS2

dbSNP Gene:57380 MRS2

ENSEMBL:ENSG00000124532 MRS2

HGNC:13785 MRS2

KEGG:hsa:57380 MRS2

Monarch:57380 MRS2

NCBI Gene:57380 MRS2

OMIM:619307 MRS2

UCSC:Q9HD23 MRS2

Reference Transcript

Other Identifiers

11725681_s_at

11725682_x_at

11725683_at

11745838_a_at

11752747_a_at

11752748_x_at

11759577_at

17005348

218536_PM_at

218536_at

218538_PM_s_at

218538_s_at

224101_3p_x_at

224101_PM_x_at

224101_x_at

228542_PM_at

228542_at

244844_PM_at

244844_at

2898453

2898454

2898455

2898456

2898459

2898462

2898463

2898464

2898465

2898470

2898471

2898472

2898473

2898474

2898475

2898476

2898477

2898479

2898480

2898481

2898482

2898483

2898484

2898485

2898486

2898487

2898488

2898490

2898492

34687_at

57056_s_at

57380

76369_at

76371_g_at

80072_at

8117194

92044_at

92045_g_at

A_14_P111162

A_14_P130852

A_23_P111373

A_24_P934744

A_33_P3255814

A_33_P3372281

GE54473

GE80457

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006089

GO:0006811

GO:0015095

GO:0016020

GO:0043226

GO:0045016

GO:0055085

HMNXSV003021031

HMNXSV003053298

Hs.146030.0.A1_3p_at

Hs.30057.0.S2_3p_at

Hs.30057.2.S1_3p_at

ILMN_1778677

PH_hs_0022611

TC06000144.hg

g10190701_3p_a_at

Inferred To

MRS2 [mitochondrial inner membrane] (Bos taurus)

MRS2 [mitochondrial inner membrane] (Canis familiaris)

MRS2 [mitochondrial inner membrane] (Dictyostelium discoideum)

MRS2 [mitochondrial inner membrane] (Gallus gallus)

MRS2 [mitochondrial inner membrane] (Plasmodium falciparum)

MRS2 [mitochondrial inner membrane] (Sus scrofa)

Mrs2 [mitochondrial inner membrane] (Mus musculus)

Mrs2 [mitochondrial inner membrane] (Rattus norvegicus)

mrs2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

mrs2 [mitochondrial inner membrane] (Xenopus tropicalis)

MFM1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of MRS2 [mitochondrial inner membrane] (Plasmodium falciparum)

Cross References

OpenTargets

ENSG00000124532

ENSEMBL

ENST00000443868, ENSP00000399585, ENSP00000367604, ENSP00000367637, ENST00000378386, ENST00000378353

HPA

ENSG00000124532-MRS2

PRO

Q9HD23

Pharos - Targets

Q9HD23

HMDB Protein

HMDBP08762

PDB

8IP3, 8IP6, 8IP4, 8TUP, 8TUL, 8IP5

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.527	2
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.527	2
UniProt:Q6ZMH5 SLC39A5	1	SLC39A5 [plasma membrane] (R-HSA-442360)	0.527	2
UniProt:Q6ZT07 TBCD9			0.527	2
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.527	3
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.527	2
UniProt:Q9NZE8 MRPL35	1	MRPL35 [mitochondrial inner membrane] (R-HSA-5368235)	0.527	2
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.527	2
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	3
UniProt:Q9Y6E2 5MP1			0.527	3
UniProt:Q99689 FEZ1			0.527	2
UniProt:Q96JJ6 JPH4			0.527	2
UniProt:Q8N5V2 NGEF	2	NGEF [cytosol] (R-HSA-3006800) p-Y179-NGEF [cytosol] (R-HSA-3928441)	0.527	3
UniProt:Q92633 LPAR1	1	LPAR1 [plasma membrane] (R-HSA-419354)	0.527	2
UniProt:Q9H0U9 TSYL1			0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:Q9P0J7 KCMF1	2	KCMF1 [extracellular region] (R-HSA-6806467) KCMF1 [ficolin-1-rich granule lumen] (R-HSA-6801525)	0.527	2
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P04618 rev	3	REV (P04618) protein [extracellular region] (R-HIV-174998) REV (P04618) protein [nucleoplasm] (R-HIV-175380) REV (P04618) protein [cytosol] (R-HIV-173267)	0.462	2

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