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ITPR2 [platelet dense tubular network membrane]
Stable Identifier
R-HSA-418281
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet dense tubular network membrane
Synonyms
Inositol 1,4,5-trisphosphate receptor type 2, ITPR2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR2 [platelet dense tubular network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14571 ITPR2
Gene Names
ITPR2
Chain
chain:1-2701
Reference Genes
BioGPS Gene:3709 ITPR2
COSMIC (genes):ITPR2 ITPR2
CTD Gene:3709 ITPR2
dbSNP Gene:3709 ITPR2
ENSEMBL:ENSG00000123104 ITPR2
HGNC:6181 ITPR2
KEGG:hsa:3709 ITPR2
Monarch:3709 ITPR2
NCBI Gene:3709 ITPR2
OMIM:600144 ITPR2
UCSC:Q14571 ITPR2
Reference Transcript
RefSeq:NM_002223.3 ITPR2
Other Identifiers
11739537_a_at
11739538_at
11758527_s_at
16762489
202660_PM_at
202660_at
202661_PM_at
202661_at
202662_PM_s_at
202662_s_at
211360_PM_s_at
211360_s_at
33839_at
3448179
3448180
3448181
3448182
3448183
3448184
3448185
3448186
3448187
3448188
3448189
3448190
3448213
3448214
3448215
3448216
3448226
3448227
3448228
3448229
3448233
3448234
3448236
3448237
3448239
3448240
3448241
3448251
3448254
3448257
3448258
3448259
3448260
3448261
3448262
3448263
3448264
3448265
3448273
3448276
3448277
3448281
3448283
3448285
3448286
3448287
3448288
3448289
3448290
3448293
3448294
3448296
3448298
3448300
3448302
3448303
3448304
3448316
3448317
3448318
3448320
3448321
3448323
3448324
3448325
3448332
3448334
3448335
3448336
3448337
3448338
3448339
3448342
3448343
3448344
3448345
3448346
3448347
3448348
3448349
3448350
3448352
3448355
3448356
3448366
3448379
3448380
3709
60842_at
756_at
7961900
A_23_P203933
A_33_P3232294
A_33_P3298128
D26350_at
GE61023
GO:0001666
GO:0005215
GO:0005216
GO:0005220
GO:0005262
GO:0005509
GO:0005524
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005938
GO:0006811
GO:0006816
GO:0007165
GO:0008289
GO:0012505
GO:0015085
GO:0015278
GO:0016020
GO:0016529
GO:0019722
GO:0030658
GO:0030667
GO:0031095
GO:0031410
GO:0033017
GO:0035091
GO:0043226
GO:0043231
GO:0043235
GO:0044325
GO:0046872
GO:0051209
GO:0055085
GO:0070588
GO:0070679
GO:0071320
GO:0071361
GO:0097110
HMNXSV003022747
Hs.238272.0.A2_3p_at
Hs.238272.0.A3_3p_at
ILMN_1736103
PH_hs_0026739
TC12001328.hg
g3786317_3p_a_at
g4504792_3p_a_at
Participates
as a member of
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
Other forms of this molecule
ITPR2 [endoplasmic reticulum membrane]
Inferred To
itpr2 [platelet dense tubular network membrane]
(Xenopus tropicalis)
ITPR2 [platelet dense tubular network membrane]
(Bos taurus)
ITPR2 [platelet dense tubular network membrane]
(Caenorhabditis elegans)
ITPR2 [platelet dense tubular network membrane]
(Canis familiaris)
ITPR2 [platelet dense tubular network membrane]
(Dictyostelium discoideum)
ITPR2 [platelet dense tubular network membrane]
(Drosophila melanogaster)
ITPR2 [platelet dense tubular network membrane]
(Gallus gallus)
ITPR2 [platelet dense tubular network membrane]
(Mus musculus)
ITPR2 [platelet dense tubular network membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_002214.2
Guide to Pharmacology - Targets
744
ENSEMBL
ENST00000242737
,
ENSP00000242737
,
ENSP00000370744
,
ENST00000381340
OpenTargets
ENSG00000123104
HPA
ENSG00000123104-ITPR2
PRO
Q14571
Pharos - Targets
Q14571
GlyGen
Q14571
Orphanet
ITPR2
HMDB Protein
HMDBP07745
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
UniProt:Q9H244 P2RY12
1
P2RY12 [plasma membrane]
(R-HSA-391959)
0.527
2
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.527
2
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