P2RY12 binds ADP

Stable Identifier
R-HSA-417829
Type
Reaction
Species
Homo sapiens
Compartment
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P2RY12 (Bodor et al. 2003) is found on the surface of blood platelet cells and is an important regulator in blood clotting. It is one of two ADP receptors expressed in platelets, the other is P2RY1. Activation leads to irreversible platelet aggregation. Defects in this receptor are associated with bleeding disorders. Its preferred ligand is ADP. The platelet anticoagulant drug clopidogrel binds to this receptor (Hollopeter G et al. 2001).

Literature References
PubMed ID Title Journal Year
12560222 Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

Kim, S, Dorsam, RT, Ding, Z, Jin, J, Kunapuli, SP

Blood 2003
14573771 Purification and functional reconstitution of the human P2Y12 receptor

Hooks, SB, Boyer, JL, Bodor, ET, Waldo, GL, Harden, TK, Corbitt, J

Mol Pharmacol 2003
11196645 Identification of the platelet ADP receptor targeted by antithrombotic drugs

Vincent, D, Conley, PB, Yang, RB, Jantzen, HM, England, L, Li, G, Julius, D, Ramakrishnan, V, Nurden, A, Nurden, P, Hollopeter, G

Nature 2001
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