Reactome | ITPR2 [endoplasmic reticulum membrane]

ITPR2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-3006467

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Inositol 1,4,5-trisphosphate receptor type 2, ITPR2_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
        
        IP3 receptor homotetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        IP3 receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
        
        AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
        
        ITPR2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14571 ITPR2

Gene Names

ITPR2

Chain

chain:1-2701

Reference Genes

BioGPS Gene:3709 ITPR2

COSMIC (genes):ITPR2 ITPR2

CTD Gene:3709 ITPR2

dbSNP Gene:3709 ITPR2

ENSEMBL:ENSG00000123104 ITPR2

ENSEMBL_homo_sapiens_GENE:ENSG00000123104.12 ITPR2

HGNC:6181 ITPR2

KEGG Gene (Homo sapiens):3709 ITPR2

Monarch:3709 ITPR2

NCBI Gene:3709 ITPR2

OMIM:600144 ITPR2

UCSC:Q14571 ITPR2

Reference Transcript

RefSeq:NM_002223.3 ITPR2

Other Identifiers

11739537_a_at

11739538_at

11758527_s_at

16762489

202660_PM_at

202660_at

202661_PM_at

202661_at

202662_PM_s_at

202662_s_at

211360_PM_s_at

211360_s_at

33839_at

3448179

3448180

3448181

3448182

3448183

3448184

3448185

3448186

3448187

3448188

3448189

3448190

3448214

3448215

3448216

3448227

3448228

3448229

3448233

3448236

3448237

3448239

3448240

3448241

3448251

3448254

3448257

3448258

3448259

3448260

3448262

3448264

3448265

3448273

3448276

3448277

3448281

3448283

3448285

3448286

3448287

3448288

3448289

3448290

3448294

3448296

3448298

3448300

3448302

3448303

3448304

3448316

3448317

3448318

3448320

3448321

3448323

3448324

3448325

3448332

3448334

3448335

3448339

3448342

3448343

3448346

3448347

3448348

3448350

3448352

3448355

3448366

3448379

3448380

3709

60842_at

756_at

7961900

A_23_P203933

A_33_P3232294

A_33_P3298128

D26350_at

GE61023

GO:0001666

GO:0005215

GO:0005216

GO:0005220

GO:0005262

GO:0005509

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005938

GO:0006811

GO:0006816

GO:0007165

GO:0008289

GO:0012505

GO:0015085

GO:0015278

GO:0016020

GO:0016529

GO:0023052

GO:0030667

GO:0031095

GO:0031410

GO:0033017

GO:0034220

GO:0035091

GO:0043226

GO:0043231

GO:0043235

GO:0044325

GO:0051209

GO:0055065

GO:0055085

GO:0070588

GO:0070679

GO:0071320

GO:0071361

GO:0097110

HMNXSV003022747

Hs.238272.0.A2_3p_at

Hs.238272.0.A3_3p_at

ILMN_1736103

PH_hs_0026739

TC12001328.hg

g3786317_3p_a_at

g4504792_3p_a_at

Participates

as a component of

as a member of

IP3 receptors [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ITPR2 [platelet dense tubular network membrane]

Inferred To

ITPR2 [endoplasmic reticulum membrane] (Bos taurus)

ITPR2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ITPR2 [endoplasmic reticulum membrane] (Canis familiaris)

ITPR2 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ITPR2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

ITPR2 [endoplasmic reticulum membrane] (Gallus gallus)

ITPR2 [endoplasmic reticulum membrane] (Mus musculus)

ITPR2 [endoplasmic reticulum membrane] (Rattus norvegicus)

itpr2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002214.2

Guide to Pharmacology - Targets

744

OpenTargets

ENSG00000123104

HPA

ENSG00000123104-ITPR2

GeneCards

Q14571

Ensembl

ENSP00000370744, ENST00000381340, ENST00000242737, ENSG00000123104, ENSP00000242737

PRO

Q14571

Pharos - Targets

Q14571

Orphanet

25121

HMDB Protein

HMDBP07745

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.527	2

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