SUMOylation of PML with SUMO3

Stable Identifier
Reaction [transition]
Homo sapiens
Conjugation of SUMO3 to PML
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PML is observed to be SUMOylated with SUMO3 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998). SUMO3 is almost identical with SUMO2 therefore the same E3 ligase (RANBP2) that SUMOylate PML with SUMO2 may also be active with SUMO3, but this has not been proven. PML colocalizes with SUMO3 in nuclear bodies and disruption of SUMO3 expression reduces the number of nuclear bodies (Fu et al. 2005).

Literature References
PubMed ID Title Journal Year
16608850 Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3

Yeh, ET, Gong, L

J. Biol. Chem. 2006
15940266 Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3

Yang, Z, Fu, C, Zhu, Y, Ding, X, Ding, H, Lan, J, Huang, H, Shi, Y, Ahmed, K, Miao, Y, Yao, X, Zhu, J

Oncogene 2005
9452416 Covalent modification of PML by the sentrin family of ubiquitin-like proteins

Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K

J. Biol. Chem. 1998
Catalyst Activity

SUMO transferase activity of SUMO3:UBE2I [nucleoplasm]

Orthologous Events
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