Reactome | SUMOylation of PML with SUMO3

SUMOylation of PML with SUMO3

Stable Identifier

R-HSA-3000433

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Conjugation of SUMO3 to PML

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PML is observed to be SUMOylated with SUMO3 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998). SUMO3 is almost identical with SUMO2 therefore the same E3 ligase (RANBP2) that SUMOylate PML with SUMO2 may also be active with SUMO3, but this has not been proven. PML colocalizes with SUMO3 in nuclear bodies and disruption of SUMO3 expression reduces the number of nuclear bodies (Fu et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Gong, L, Yeh, ET	J. Biol. Chem.	2006
15940266	Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3 Fu, C, Ahmed, K, Ding, H, Ding, X, Lan, J, Yang, Z, Miao, Y, Zhu, Y, Shi, Y, Zhu, J, Huang, H, Yao, X	Oncogene	2005
9452416	Covalent modification of PML by the sentrin family of ubiquitin-like proteins Kamitani, T, Nguyen, HP, Kito, K, Fukuda-Kamitani, T, Yeh, ET	J. Biol. Chem.	1998