Oligomerization of BCL10 and MALT1

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BCL10 and MALT1 proteins form high molecular weight oligomers and only these oligomeric forms can activate IKK in vitro (Sun et al. 2004). BCL10 proteins form homo-oligomers through CARD-CARD interactions whereas in MALT1 the tandem Ig-like domains naturally form oligomers with a tendency towards dimers and tetramers (Dong et al. 2006, Quiu & Dhe-Paganon 2011). These CBM oligomers provides the molecular platform, which can facilitate dimerization or serve as scaffolds on which proteases and kinases involved in NF-kB activation are assembled and activated.

Literature References
PubMed ID Title Journal Year
21966355 Oligomeric structure of the MALT1 tandem Ig-like domains

Qiu, L, Dhe-Paganon, S

PLoS ONE 2011
16831874 The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

Zou, T, Liu, Z, Liu, Y, Xiao, H, Peng, J, Chen, L, Bu, Y, Dong, W, Qi, Y, Li, W

J Biol Chem 2006
Orthologous Events
Cite Us!