Reactome | Oligomerization of BCL10 and MALT1

Oligomerization of BCL10 and MALT1

Stable Identifier

R-HSA-2730899

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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BCL10 and MALT1 proteins form high molecular weight oligomers and only these oligomeric forms can activate IKK in vitro (Sun et al. 2004). BCL10 proteins form homo-oligomers through CARD-CARD interactions whereas in MALT1 the tandem Ig-like domains naturally form oligomers with a tendency towards dimers and tetramers (Dong et al. 2006, Quiu & Dhe-Paganon 2011). These CBM oligomers provides the molecular platform, which can facilitate dimerization or serve as scaffolds on which proteases and kinases involved in NF-kB activation are assembled and activated.

Literature References

PubMed ID	Title	Journal	Year
21966355	Oligomeric structure of the MALT1 tandem Ig-like domains Qiu, L, Dhe-Paganon, S	PLoS ONE	2011
16831874	The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4 Dong, W, Liu, Y, Peng, J, Chen, L, Zou, T, Xiao, H, Liu, Z, Li, W, Bu, Y, Qi, Y	J Biol Chem	2006