Reactome | MALT1 oligomerizes

MALT1 oligomerizes

Stable Identifier

R-HSA-5607736

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).

Literature References

PubMed ID	Title	Journal	Year
24074955	Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly Qiao, Q, Yang, C, Zheng, C, Fontán, L, David, L, Yu, X, Bracken, C, Rosen, M, Melnick, A, Egelman, EH, Wu, H	Mol. Cell	2013
21966355	Oligomeric structure of the MALT1 tandem Ig-like domains Qiu, L, Dhe-Paganon, S	PLoS ONE	2011
11262391	Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway Lucas, PC, Yonezumi, M, Inohara, N, McAllister-Lucas, LM, Abazeed, ME, Chen, FF, Yamaoka, S, Seto, M, Nunez, G	J. Biol. Chem.	2001