Reactome | MALT1 oligomerizes

MALT1 oligomerizes

Stable Identifier

R-HSA-5607736

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).

Literature References

PubMed ID	Title	Journal	Year
21966355	Oligomeric structure of the MALT1 tandem Ig-like domains Qiu, L, Dhe-Paganon, S	PLoS ONE	2011
24074955	Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly David, L, Qiao, Q, Yang, C, Fontán, L, Wu, H, Melnick, A, Egelman, EH, Rosen, M, Bracken, C, Yu, X, Zheng, C	Mol. Cell	2013
11262391	Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway Nunez, G, Inohara, N, Lucas, PC, Abazeed, ME, Chen, FF, Seto, M, Yamaoka, S, McAllister-Lucas, LM, Yonezumi, M	J. Biol. Chem.	2001