MALT1 oligomerizes

Stable Identifier
R-HSA-5607736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MALT1 oligomerizes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).

Literature References
PubMed ID Title Journal Year
24074955 Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly

Qiao, Q, Yang, C, Zheng, C, Fontán, L, David, L, Yu, X, Bracken, C, Rosen, M, Melnick, A, Egelman, EH, Wu, H

Mol. Cell 2013
21966355 Oligomeric structure of the MALT1 tandem Ig-like domains

Qiu, L, Dhe-Paganon, S

PLoS ONE 2011
11262391 Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Lucas, PC, Yonezumi, M, Inohara, N, McAllister-Lucas, LM, Abazeed, ME, Chen, FF, Yamaoka, S, Seto, M, Nunez, G

J. Biol. Chem. 2001
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
MALT1 oligomerizes (Bos taurus)
MALT1 oligomerizes (Canis familiaris)
MALT1 oligomerizes (Gallus gallus)
MALT1 oligomerizes (Mus musculus)
MALT1 oligomerizes (Rattus norvegicus)
MALT1 oligomerizes (Sus scrofa)
MALT1 oligomerizes (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)