MALT1 oligomerizes

Stable Identifier
Reaction [Polymerisation]
Homo sapiens
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After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).

Literature References
PubMed ID Title Journal Year
21966355 Oligomeric structure of the MALT1 tandem Ig-like domains

Qiu, L, Dhe-Paganon, S

PLoS ONE 2011
24074955 Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly

David, L, Qiao, Q, Yang, C, Fontán, L, Wu, H, Melnick, A, Egelman, EH, Rosen, M, Bracken, C, Yu, X, Zheng, C

Mol. Cell 2013
11262391 Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Nunez, G, Inohara, N, Lucas, PC, Abazeed, ME, Chen, FF, Seto, M, Yamaoka, S, McAllister-Lucas, LM, Yonezumi, M

J. Biol. Chem. 2001
Orthologous Events
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