After binding BCL10, MALT1 also undergoes oligomerization. Like traditional caspases, MALT1 also becomes activated through the formation of oligomers. Once the CARD9-BCL10-MALT1 (CBM) signalosome is assembled, MALT1 functions as the effector protein and mediates activation of the IKK complex (McAllister-Lucas & Lucas 2008).
Qiu, L, Dhe-Paganon, S
David, L, Qiao, Q, Yang, C, Fontán, L, Wu, H, Melnick, A, Egelman, EH, Rosen, M, Bracken, C, Yu, X, Zheng, C
Nunez, G, Inohara, N, Lucas, PC, Abazeed, ME, Chen, FF, Seto, M, Yamaoka, S, McAllister-Lucas, LM, Yonezumi, M
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