Reactome | CARMA1 recruits MALT1 and BCL10 forming CBM Complex

CARMA1 recruits MALT1 and BCL10 forming CBM Complex

Stable Identifier

R-HSA-1168644

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Formation of CBM Complex

ReviewStatus

5/5

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CARMA1 recruits MALT1 and BCL10 forming CBM Complex

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CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).

Literature References

PubMed ID	Title	Journal	Year
17428801	CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation Tanner, MJ, Lin, X, Gaffen, SL, Hanel, W	J Biol Chem	2007
16356855	Phosphorylation of the CARMA1 linker controls NF-kappaB activation Sommer, K, Pomerantz, JL, Rawlings, DJ, Guo, B, Bandaranayake, AD, Ovechkina, YL, Moreno-Garcia, ME	Immunity	2005
14695475	Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO Dixit, VM, O'Rourke, K, Eby, M, Ultsch, M, Xiao, W, Wertz, I, Zhou, H, Seshagiri, S	Nature	2004