CARMA1 recruits MALT1 and BCL10 forming CBM Complex

Stable Identifier
R-HSA-1168644
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Formation of CBM Complex
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CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).

Literature References
PubMed ID Title Journal Year
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Guo, B, Pomerantz, JL, Bandaranayake, AD, Moreno-Garcia, ME, Ovechkina, YL, Rawlings, DJ

Immunity 2005
17428801 CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation

Tanner, MJ, Hanel, W, Gaffen, SL, Lin, X

J Biol Chem 2007
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Zhou, H, Wertz, I, O'Rourke, K, Ultsch, M, Seshagiri, S, Eby, M, Xiao, W, Dixit, VM

Nature 2004
Participants
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Orthologous Events
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