CARMA1 recruits MALT1 and BCL10 forming CBM Complex

Stable Identifier
R-HSA-1168644
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Formation of CBM Complex
ReviewStatus
5/5
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CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).
Literature References
PubMed ID Title Journal Year
17428801 CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation

Tanner, MJ, Lin, X, Gaffen, SL, Hanel, W

J Biol Chem 2007
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Pomerantz, JL, Rawlings, DJ, Guo, B, Bandaranayake, AD, Ovechkina, YL, Moreno-Garcia, ME

Immunity 2005
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Dixit, VM, O'Rourke, K, Eby, M, Ultsch, M, Xiao, W, Wertz, I, Zhou, H, Seshagiri, S

Nature 2004
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