CARMA1 recruits MALT1 and BCL10 forming CBM Complex

Stable Identifier
R-HSA-1168644
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Formation of CBM Complex
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CARMA1 recruits MALT1 and BCL10 forming CBM Complex
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CARMA1 is phosphorylated and recruits BCL10 and MALT1 to the plasma membrane to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007). Evidence from T cells (Jurkat cells) indicates that MALT1 and BCL10 oligomerize to activate the IKK complex (Zhou 2004).

Literature References
PubMed ID Title Journal Year
17428801 CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation

Tanner, MJ, Lin, X, Gaffen, SL, Hanel, W

J Biol Chem 2007
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Pomerantz, JL, Rawlings, DJ, Guo, B, Bandaranayake, AD, Ovechkina, YL, Moreno-Garcia, ME

Immunity 2005
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Dixit, VM, O'Rourke, K, Eby, M, Ultsch, M, Xiao, W, Wertz, I, Zhou, H, Seshagiri, S

Nature 2004
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Orthologous Events
CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Canis familiaris)
CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)
CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Mus musculus)
CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)
Authored
May, B  (2010-12-18)
Reviewed
Wienands, J  (2012-02-11)
Created
May, B  (2011-01-03)
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