MALT1 binds BCL10

Stable Identifier
R-HSA-5607744
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is the main downstream target of BCL10. MALT1 interacts directly with BCL10 and this interaction involves a short stretch of amino acids that follow the BCL10 CARD motif (amino acids 107–119 of human BCL10) and the two immunoglobulin-like domains of MALT1 (Uren et al. 2000, Lucas et al. 2001).

Literature References
PubMed ID Title Journal Year
11090634 Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

Uren, AG, O'Rourke, K, Aravind, LA, Pisabarro, MT, Seshagiri, S, Koonin, EV, Dixit, VM

Mol. Cell 2000
11262391 Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

Lucas, PC, Yonezumi, M, Inohara, N, McAllister-Lucas, LM, Abazeed, ME, Chen, FF, Yamaoka, S, Seto, M, Nunez, G

J. Biol. Chem. 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created