Reactome | malt1 [cytosol]

malt1 [cytosol]

Stable Identifier

R-XTR-202461

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

MALT1, A0A8J0QUQ5

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)
    - Downstream signaling events of B Cell Receptor (BCR) (Xenopus tropicalis)
      - Activation of NF-kappaB in B cells (Xenopus tropicalis)
        
        CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
  - TCR signaling (Xenopus tropicalis)
    - Downstream TCR signaling (Xenopus tropicalis)
      - Activation of IKK complex (Xenopus tropicalis)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Xenopus tropicalis)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Activation of TAK1-TAB2 complex (Xenopus tropicalis)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Xenopus tropicalis)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Interaction and oligomerization of MALT1 to Bcl10 (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Translocation of TRAF6 to CBM complex (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 trimer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - C-type lectin receptors (CLRs) (Xenopus tropicalis)
    - CLEC7A (Dectin-1) signaling (Xenopus tropicalis)
      - K63polyUb-TAK1 autophosphorylates (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - MALT1 binds BCL10 (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - MALT1 oligomerizes (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - TRAF6 binds MALT1 oligomers (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - TRAF6 oligomerizes (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - TRIKA2 binds K63polyUb-TRAF6 oligomer (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated NF-kB activation (Xenopus tropicalis)
      - Activation of TAK1 complex bound to pUb-TRAF6 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Oligomerization of BCL10 and MALT1 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM complex [plasma membrane] (Xenopus tropicalis)
        
        p-CARMA1 oligomer:BCL10:MALT1 (CBM complex) [plasma membrane] (Xenopus tropicalis)
        
        BCL10:MALT1 [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Oligomerization of TRAF6 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Xenopus tropicalis)
        
        MALT1oligomer:TRAF6 [cytosol] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of IKK-beta by TAK1 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
      - Recruitment of TRAF6 to CBM complex by binding to MALT1 (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer [plasma membrane] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        CBM oligomer:TRAF6 [plasma membrane] (Xenopus tropicalis)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Xenopus tropicalis)
        
        MALT1oligomer:TRAF6 [cytosol] (Xenopus tropicalis)
        
        MALT1 oligomer [cytosol] (Xenopus tropicalis)
        
        malt1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A8J0QUQ5

Gene Names

malt1

Reference Genes

BioGPS Gene:100493493 malt1

ENSEMBL:ENSXETG00000021146

Monarch:100493493 malt1

NCBI Gene:100493493 malt1

UCSC:A0A8J0QUQ5 malt1

Reference Transcript

RefSeq:XM_004910398.4 malt1

Participates

as an input of

as a component of

as a repeated unit of

MALT1 oligomer [cytosol] (Xenopus tropicalis)

Inferred From

MALT1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_004910455.1

Xenbase

XB-GENE-491810

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